Plant asparaginyl endopeptidases and their structural determinants of function.
peptides
plant proteins
protein structure
proteolysis
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
30 04 2021
30 04 2021
Historique:
received:
18
12
2020
revised:
09
02
2021
accepted:
10
02
2021
pubmed:
6
3
2021
medline:
29
1
2022
entrez:
5
3
2021
Statut:
ppublish
Résumé
Asparaginyl endopeptidases (AEPs) are versatile enzymes that in biological systems are involved in producing three different catalytic outcomes for proteins, namely (i) routine cleavage by bond hydrolysis, (ii) peptide maturation, including macrocyclisation by a cleavage-coupled intramolecular transpeptidation and (iii) circular permutation involving separate cleavage and transpeptidation reactions resulting in a major reshuffling of protein sequence. AEPs differ in their preference for cleavage or transpeptidation reactions, catalytic efficiency, and preference for asparagine or aspartate target residues. We look at structural analyses of various AEPs that have laid the groundwork for identifying important determinants of AEP function in recent years, with much of the research impetus arising from the potential biotechnological and pharmaceutical applications.
Identifiants
pubmed: 33666219
pii: 228026
doi: 10.1042/BST20200908
pmc: PMC8106488
doi:
Substances chimiques
Peptides
0
Plant Proteins
0
Seed Storage Proteins
0
Cysteine Endopeptidases
EC 3.4.22.-
asparaginylendopeptidase
EC 3.4.22.34
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
965-976Informations de copyright
© 2021 The Author(s).
Références
J Biol Chem. 1995 Jul 14;270(28):16645-52
pubmed: 7622473
Nat Chem Biol. 2014 Sep;10(9):732-8
pubmed: 25038786
Nat Commun. 2015 Dec 18;6:10199
pubmed: 26680698
J Biol Chem. 2007 Oct 5;282(40):29721-8
pubmed: 17698845
Cell Res. 2014 Mar;24(3):344-58
pubmed: 24407422
Elife. 2018 Jan 31;7:
pubmed: 29384475
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11737-11746
pubmed: 31123145
Chem Rev. 2006 Mar;106(3):840-95
pubmed: 16522011
Plant Mol Biol. 1999 Jan;39(1):63-73
pubmed: 10080709
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):24-31
pubmed: 22232165
J Mol Biol. 2001 Jan 12;305(2):291-305
pubmed: 11124907
Nat Commun. 2018 Jun 20;9(1):2411
pubmed: 29925835
Biochemistry. 2004 May 25;43(20):5965-75
pubmed: 15147180
J Am Chem Soc. 2019 Oct 30;141(43):17388-17393
pubmed: 31573802
Plant Cell. 2012 Jul;24(7):2765-78
pubmed: 22822203
J Biol Chem. 1993 Feb 15;268(5):3525-9
pubmed: 8429028
J Biol Chem. 1986 Aug 25;261(24):11124-30
pubmed: 3755437
Nat Struct Mol Biol. 2012 Aug;19(8):767-72
pubmed: 22796963
J Am Chem Soc. 2017 Apr 19;139(15):5351-5358
pubmed: 28199119
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10940-5
pubmed: 23776206
Planta. 1983 May;157(6):536-9
pubmed: 24264419
Plant Cell. 2018 Mar;30(3):686-699
pubmed: 29453229
FEBS Lett. 1991 Dec 2;294(1-2):89-93
pubmed: 1743299
Org Lett. 2019 Apr 5;21(7):2029-2032
pubmed: 30763108
Anal Chem. 2014 Sep 16;86(18):9091-7
pubmed: 25133655
Exp Cell Res. 1971 Jan;64(1):232-6
pubmed: 5541973
Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15694-8
pubmed: 26563575
J Nat Prod. 2010 Dec 27;73(12):1987-92
pubmed: 21070025
J Exp Bot. 2018 Jan 23;69(3):633-641
pubmed: 29309615
J Nat Prod. 2019 Aug 23;82(8):2152-2158
pubmed: 31392883
Int J Mol Sci. 2018 Dec 21;20(1):
pubmed: 30577614
J Am Chem Soc. 2016 Jun 8;138(22):6968-71
pubmed: 27206099
BMC Struct Biol. 2008 Dec 12;8:54
pubmed: 19077275
Curr Pharm Des. 2011 Dec;17(38):4294-307
pubmed: 22204428
J Biol Chem. 2013 May 3;288(18):12500-10
pubmed: 23486480
Chem Rev. 2019 Dec 26;119(24):12375-12421
pubmed: 31829013
J Med Chem. 2014 Jan 23;57(2):278-95
pubmed: 24044773
Nat Prod Rep. 2013 Jan;30(1):108-60
pubmed: 23165928
FEBS J. 2008 Jun;275(11):2684-90
pubmed: 18435757
Plant Cell. 1998 Mar;10(3):343-57
pubmed: 9501109
Plant Physiol. 1987 Oct;85(2):440-5
pubmed: 16665717
Science. 1908 Oct 2;28(718):417-27
pubmed: 17771936
J Mol Biol. 1999 Jul 9;290(2):525-33
pubmed: 10390350
FASEB J. 1990 Nov;4(14):3198-208
pubmed: 2227211
Nature. 1985 Jan 3-9;313(5997):64-7
pubmed: 3965973
Plant J. 2008 Feb;53(3):505-15
pubmed: 18086282
Chem Commun (Camb). 2015 Dec 18;51(97):17289-92
pubmed: 26462854
BMC Plant Biol. 2017 Jan 6;17(1):4
pubmed: 28061816
Plant Cell. 2004 Jan;16(1):270-90
pubmed: 14688293
Nat Chem Biol. 2011 May;7(5):257-9
pubmed: 21423169
Biotechnol Adv. 2020 Dec;45:107651
pubmed: 33141031
J Biol Chem. 2012 Aug 10;287(33):28037-46
pubmed: 22700963
J Biol Chem. 2020 Sep 11;295(37):13047-13064
pubmed: 32719006
J Nat Prod. 2020 Oct 23;83(10):3030-3040
pubmed: 32997497
Enzyme Microb Technol. 1991 Apr;13(4):290-5
pubmed: 1367163
Curr Biol. 1991 Apr;1(2):71-3
pubmed: 15336168
J Biol Chem. 2003 Aug 22;278(34):32292-9
pubmed: 12799370
ACS Catal. 2017 Sep 1;7(9):5585-5593
pubmed: 28932620
J Biol Chem. 2004 Nov 5;279(45):46858-67
pubmed: 15328347
J Cell Biol. 1986 Apr;102(4):1284-97
pubmed: 3958046
J Am Chem Soc. 2015 Dec 16;137(49):15398-401
pubmed: 26633100
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10614-9
pubmed: 11535828
Front Plant Sci. 2015 Apr 09;6:234
pubmed: 25914711
Chem Sci. 2020 May 12;11(23):5881-5888
pubmed: 32874509
Plant Cell. 2014 Mar;26(3):981-95
pubmed: 24681618
Nat Prod Rep. 2018 Feb 21;35(2):137-146
pubmed: 29379937
Chem Rev. 1998 Apr 2;98(2):637-674
pubmed: 11848911
Curr Pharm Des. 2011 Dec;17(38):4308-17
pubmed: 22204429
Nat Commun. 2020 Mar 27;11(1):1575
pubmed: 32221295
Chem Biol. 2015 May 21;22(5):571-82
pubmed: 25960260
Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7822-7825
pubmed: 28524544
New Phytol. 2020 Apr;226(1):21-31
pubmed: 31679161
ACS Chem Biol. 2019 May 17;14(5):979-993
pubmed: 30973714
Nat Protoc. 2016 Oct;11(10):1977-1988
pubmed: 27658013
Sci Rep. 2019 Jul 25;9(1):10820
pubmed: 31346249
New Phytol. 2018 May;218(3):923-928
pubmed: 28322452
Plant Cell Physiol. 2002 Feb;43(2):143-51
pubmed: 11867693
Plant Cell. 1995 Jul;7(7):945-56
pubmed: 7640527
Mol Biol Evol. 2017 Jun 1;34(6):1505-1516
pubmed: 28333296
Toxins (Basel). 2012 Feb;4(2):139-56
pubmed: 22474571
Nature. 2000 Sep 14;407(6801):215-8
pubmed: 11001063
J Biol Chem. 2018 Jun 8;293(23):8934-8946
pubmed: 29628443
Trends Plant Sci. 2002 Aug;7(8):340-4
pubmed: 12167328
Expert Opin Drug Discov. 2016 Dec;11(12):1151-1163
pubmed: 27718641
Plant Direct. 2018 Feb;2(2):
pubmed: 30417166
J Biol Chem. 1999 Jan 22;274(4):2563-70
pubmed: 9891029
Biochimie. 2016 Mar;122:126-50
pubmed: 26403494
Arch Biochem Biophys. 1993 Jun;303(2):208-13
pubmed: 8512309
Nat Struct Biol. 1994 Aug;1(8):502-4
pubmed: 7664074
Angew Chem Int Ed Engl. 2021 Feb 19;60(8):4004-4008
pubmed: 33202079
Plant Physiol. 1995 Oct;109(2):347-52
pubmed: 7480335
Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6551-6556
pubmed: 28584123
Clin Exp Immunol. 1981 Nov;46(2):237-49
pubmed: 6461456
Biochem Biophys Res Commun. 1967 Apr 20;27(2):157-62
pubmed: 6035483
Curr Opin Chem Biol. 2017 Jun;38:24-29
pubmed: 28249193
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7395-400
pubmed: 12771376
Plant J. 2019 Jun;98(6):988-999
pubmed: 30790358
J Biochem. 1975 Oct;78(4):687-96
pubmed: 1213987