The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells.
HepaRG cells
mRNA-seq
miRNA-seq
naringenin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Feb 2021
25 Feb 2021
Historique:
received:
25
01
2021
revised:
15
02
2021
accepted:
20
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Naringenin, a natural flavonoid widely found in citrus fruits, has been reported to possess anti-oxidant, anti-inflammatory, and hepatoprotective properties as a natural dietary supplement. However, the regulatory mechanism of naringenin in human liver remains unclear. In the present study, messenger RNA sequencing (mRNA-seq), microRNA sequencing (miRNA-seq), and real-time qPCR were used to distinguish the expression differences between control and naringenin-treated HepaRG cells. We obtained 1037 differentially expressed mRNAs and 234 miRNAs. According to the target prediction and integration analysis in silico, we found 20 potential miRNA-mRNA pairs involved in liver metabolism. This study is the first to provide a perspective of miRNA-mRNA interactions in the regulation of naringenin via an integrated analysis of mRNA-seq and miRNA-seq in HepaRG cells, which further characterizes the nutraceutical value of naringenin as a food additive.
Identifiants
pubmed: 33669020
pii: ijms22052292
doi: 10.3390/ijms22052292
pmc: PMC7956767
pii:
doi:
Substances chimiques
Flavanones
0
MicroRNAs
0
RNA, Messenger
0
naringenin
HN5425SBF2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation of China
ID : No. 31571830
Organisme : Applied Science and Technology R&D Special Fund Project of Guangdong Province
ID : No. 2016B020239003
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