A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats.
3-HPPA
diacylglycerol 34:2
dysbiosis biomarkers
gut microbiota
hippurate
metabolic profile
metabolomics
metagenomics
microbial dysbiosis
o-coumaric acid
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
18 02 2021
18 02 2021
Historique:
received:
29
11
2020
revised:
06
02
2021
accepted:
13
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
24
7
2021
Statut:
epublish
Résumé
Obesity is one of the most incident and concerning disease worldwide. Definite strategies to prevent obesity and related complications remain elusive. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrimination on the different biomarkers in the obesity onset. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in
Identifiants
pubmed: 33670496
pii: biom11020303
doi: 10.3390/biom11020303
pmc: PMC7922951
pii:
doi:
Substances chimiques
Coumaric Acids
0
Phenylalanine
47E5O17Y3R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Centro para el Desarrollo Tecnológico Industrial
ID : TECNOMIFOOD
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