Modulating the Neuromodulators: Dopamine, Serotonin, and the Endocannabinoid System.

Dopamine Dopaminergic Neurons Endocannabinoids Humans Neurotransmitter Agents Reward Serotonin Ventral Tegmental Area
addiction circuits motivation neuromodulation reward

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
06 2021
Historique:
received: 04 08 2020
revised: 04 12 2020
accepted: 01 02 2021
pubmed: 7 3 2021
medline: 19 8 2021
entrez: 6 3 2021
Statut: ppublish

Résumé

Dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and endocannabinoids (ECs) are key neuromodulators involved in many aspects of motivated behavior, including reward processing, reinforcement learning, and behavioral flexibility. Among the longstanding views about possible relationships between these neuromodulators is the idea of DA and 5-HT acting as opponents. This view has been challenged by emerging evidence that 5-HT supports reward seeking via activation of DA neurons in the ventral tegmental area. Adding an extra layer of complexity to these interactions, the endocannabinoid system is uniquely placed to influence dopaminergic and serotonergic neurotransmission. In this review we discuss how these three neuromodulatory systems interact at the cellular and circuit levels. Technological advances that facilitate precise identification and control of genetically targeted neuronal populations will help to achieve a better understanding of the complex relationship between these essential systems, and the potential relevance for motivated behavior.

Identifiants

DOI: 10.1016/j.tins.2021.02.001 PMID: 33674134 PMC: PMC8159866
pubmed: 33674134
pii: S0166-2236(21)00022-9
doi: 10.1016/j.tins.2021.02.001
pmc: PMC8159866
mid: NIHMS1671315
pii:
doi:

Substances chimiques

Endocannabinoids 0
Neurotransmitter Agents 0
Serotonin 333DO1RDJY
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

464-477

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA045639
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests There are no interests to declare.

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Auteurs

Kate Z Peters (KZ)

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD, USA. Electronic address: kate.peters@som.umaryland.edu.

Joseph F Cheer (JF)

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD, USA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.

Raffaella Tonini (R)

Neuromodulation of Cortical and Subcortical Circuits Laboratory, Fondazione Istituto Italiano di Tecnologia, via Morego 30, Genova, Italy. Electronic address: raffaella.tonini@iit.it.

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questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Modulating the Neuromodulators: Dopamine,...
questionsmedicales.fr › Lipides › Acides gras › Endocannabinoïdes › Modulating the Neuromodulators: Dopamine,...
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