The impact of betamethasone on fetal pulmonary, umbilical and middle cerebral artery Doppler velocimetry and its relationship with neonatal respiratory distress syndrome.
Adult
Betamethasone
/ administration & dosage
Blood Flow Velocity
/ drug effects
Female
Fetal Organ Maturity
/ drug effects
Fetus
/ blood supply
Glucocorticoids
/ administration & dosage
Humans
Infant, Newborn
Middle Cerebral Artery
/ diagnostic imaging
Obstetric Labor, Premature
/ diagnosis
Outcome Assessment, Health Care
Pregnancy
Prenatal Care
/ methods
Pulmonary Artery
/ diagnostic imaging
Respiratory Distress Syndrome, Newborn
/ diagnosis
Ultrasonography, Doppler
/ methods
Ultrasonography, Prenatal
/ methods
Umbilical Arteries
/ diagnostic imaging
Betamethasone
Fetal lung maturity
Fetal pulmonary artery
Respiratory distress syndrome
Journal
BMC pregnancy and childbirth
ISSN: 1471-2393
Titre abrégé: BMC Pregnancy Childbirth
Pays: England
ID NLM: 100967799
Informations de publication
Date de publication:
06 Mar 2021
06 Mar 2021
Historique:
received:
19
11
2020
accepted:
22
02
2021
entrez:
7
3
2021
pubmed:
8
3
2021
medline:
21
5
2021
Statut:
epublish
Résumé
Prenatal corticosteroid administration is known to be an effective strategy in improving fetal pulmonary maturity. This study aimed to evaluate the impact of maternal betamethasone administration on fetal pulmonary and other arteries Doppler velocity and the correlation between RDS development and Doppler indices results. Fifty one singleton pregnancies between 26 and 34 gestational weeks with a diagnosis of preterm labor were included in the exposed group and received betamethasone. Fifty one uncomplicated pregnancies were included in the non-exposed group. Fetal pulmonary, umbilical and middle cerebral arteries Doppler parameters were evaluated before and 24 to 48 h after steroid administration in the exposed group and two times at same intervals in the non-exposed group. Maternal records were matched to neonatal charts if delivery happened, and demographic and outcome data were abstracted. When compared with the nonexposed group, fetuses treated with corticosteroids demonstrated significantly decreased umbilical artery Pulsatility index (PI) and significantly increased the middle cerebral artery PI, pulmonary artery Acceleration time (AT) and pulmonary artery AT/ET (Ejection time), while all other indices remained similar. We found significantly decreased pulmonary artery AT in the fetuses with respiratory distress syndrome (RDS) compared to those that did not. The results of our study showed that maternal antenatal betamethasone administration caused significant changes in the fetus blood velocity waveforms and also affected the blood flow in the pulmonary artery which led to an increase in the pulmonary artery AT and AT/ET. Among those fetuses with RDS, we found a significant decrease in the pulmonary artery AT, but we did not observe any pulmonary artery AT/ET differences.
Sections du résumé
BACKGROUND
BACKGROUND
Prenatal corticosteroid administration is known to be an effective strategy in improving fetal pulmonary maturity. This study aimed to evaluate the impact of maternal betamethasone administration on fetal pulmonary and other arteries Doppler velocity and the correlation between RDS development and Doppler indices results.
METHODS
METHODS
Fifty one singleton pregnancies between 26 and 34 gestational weeks with a diagnosis of preterm labor were included in the exposed group and received betamethasone. Fifty one uncomplicated pregnancies were included in the non-exposed group. Fetal pulmonary, umbilical and middle cerebral arteries Doppler parameters were evaluated before and 24 to 48 h after steroid administration in the exposed group and two times at same intervals in the non-exposed group. Maternal records were matched to neonatal charts if delivery happened, and demographic and outcome data were abstracted.
RESULTS
RESULTS
When compared with the nonexposed group, fetuses treated with corticosteroids demonstrated significantly decreased umbilical artery Pulsatility index (PI) and significantly increased the middle cerebral artery PI, pulmonary artery Acceleration time (AT) and pulmonary artery AT/ET (Ejection time), while all other indices remained similar. We found significantly decreased pulmonary artery AT in the fetuses with respiratory distress syndrome (RDS) compared to those that did not.
CONCLUSIONS
CONCLUSIONS
The results of our study showed that maternal antenatal betamethasone administration caused significant changes in the fetus blood velocity waveforms and also affected the blood flow in the pulmonary artery which led to an increase in the pulmonary artery AT and AT/ET. Among those fetuses with RDS, we found a significant decrease in the pulmonary artery AT, but we did not observe any pulmonary artery AT/ET differences.
Identifiants
pubmed: 33676432
doi: 10.1186/s12884-021-03655-2
pii: 10.1186/s12884-021-03655-2
pmc: PMC7937237
doi:
Substances chimiques
Glucocorticoids
0
Betamethasone
9842X06Q6M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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