Production of l-Theanine by Escherichia coli in the Absence of Supplemental Ethylamine.
Escherichia coli
alanine decarboxylase
l-theanine
theanine hydrolase
γ-glutamylmethylamide synthetase
ω-transaminase
Journal
Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
17
01
2021
accepted:
09
03
2021
pubmed:
21
3
2021
medline:
2
6
2021
entrez:
20
3
2021
Statut:
epublish
Résumé
l-Theanine is a nonproteinogenic amino acid present almost exclusively in tea plants and is beneficial for human health. For industrial production, l-theanine is enzymatically or chemically synthesized from glutamine/glutamate (or a glutamine/glutamate derivative) and ethylamine. Ethylamine is extremely flammable and toxic, which complicates and increases the cost of operational procedures. To solve these problems, we developed an artificial biosynthetic pathway to produce l-theanine in the absence of supplemental ethylamine. For this purpose, we identified and selected a novel transaminase (NCBI:protein accession number AAN70747) from
Identifiants
pubmed: 33741612
pii: AEM.00031-21
doi: 10.1128/AEM.00031-21
pmc: PMC8208135
pii:
doi:
Substances chimiques
Ethylamines
0
Glutamates
0
theanine
8021PR16QO
ethylamine
YG6MGA6AT5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 American Society for Microbiology.
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