Piggybacking on Niche Adaptation Improves the Maintenance of Multidrug-Resistance Plasmids.
antibiotic resistance
clinical isolates
experimental evolution
fitness cost
niche adaptation
plasmids
Journal
Molecular biology and evolution
ISSN: 1537-1719
Titre abrégé: Mol Biol Evol
Pays: United States
ID NLM: 8501455
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
26
10
2020
revised:
12
02
2021
accepted:
23
03
2021
pubmed:
25
3
2021
medline:
21
9
2021
entrez:
24
3
2021
Statut:
ppublish
Résumé
The persistence of plasmids in bacterial populations represents a puzzling evolutionary problem with serious clinical implications due to their role in the ongoing antibiotic resistance crisis. Recently, major advancements have been made toward resolving this "plasmid paradox" but mainly in a nonclinical context. Here, we propose an additional explanation for the maintenance of multidrug-resistance plasmids in clinical Escherichia coli strains. After coevolving two multidrug-resistance plasmids encoding resistance to last resort carbapenems with an extraintestinal pathogenic E. coli strain, we observed that chromosomal media adaptive mutations in the global regulatory systems CCR (carbon catabolite repression) and ArcAB (aerobic respiration control) pleiotropically improved the maintenance of both plasmids. Mechanistically, a net downregulation of plasmid gene expression reduced the fitness cost. Our results suggest that global chromosomal transcriptional rewiring during bacterial niche adaptation may facilitate plasmid maintenance.
Identifiants
pubmed: 33760032
pii: 6184872
doi: 10.1093/molbev/msab091
pmc: PMC8321521
doi:
Substances chimiques
Cyclic AMP Receptor Protein
0
Escherichia coli Proteins
0
crp protein, E coli
0
NDM-1 protein, E coli
EC 3.5.2.6
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3188-3201Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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