Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting.
Cost analysis
Genomics
Micro-costing
Oncology
Whole exome sequencing
Journal
The European journal of health economics : HEPAC : health economics in prevention and care
ISSN: 1618-7601
Titre abrégé: Eur J Health Econ
Pays: Germany
ID NLM: 101134867
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
23
12
2019
accepted:
16
03
2021
pubmed:
26
3
2021
medline:
18
9
2021
entrez:
25
3
2021
Statut:
ppublish
Résumé
Although high-throughput sequencing is revolutionising medicine, data on the actual cost of whole exome sequencing (WES) applications are needed. We aimed at assessing the cost of WES at a French cancer institute in 2015 and 2018. Actual costs of WES application in oncology research were determined using both micro-costing and gross-costing for the years 2015 and 2018, before and after the acquisition of a new sequencer. The entire workflow process of a WES test was tracked, and the number and unit price of each resource were identified at the most detailed level, from library preparation to bioinformatics analyses. In addition, we conducted an ad hoc analysis of the bioinformatics storage costs of data issued from WES analyses. The cost of WES has decreased substantially, from €1921 per sample (i.e. cost of €3842 per patient) in 2015 to €804 per sample (i.e. cost of €1,608 per patient) in 2018, representing a decrease of 58%. In the meantime, the cost of bioinformatics storage has increased from €19,836 to €200,711. This study suggests that WES cost has decreased significantly in recent years. WES has become affordable, even though clinical utility and efficiency still need to be confirmed.
Identifiants
pubmed: 33765190
doi: 10.1007/s10198-021-01293-1
pii: 10.1007/s10198-021-01293-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
855-864Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-10-IBHU-0001
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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