Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects.
Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/ genetics
Anthropometry
CpG Islands
DNA Methylation
Diet, Vegan
Epigenesis, Genetic
Genotype
Healthy Volunteers
Humans
Male
Middle Aged
Nutritional Sciences
Promoter Regions, Genetic
Receptor, Melanocortin, Type 4
/ genetics
Spermatozoa
/ metabolism
epigenetic
nutrition
reproduction
sperm
vegan
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
11
2020
accepted:
19
01
2021
entrez:
26
3
2021
pubmed:
27
3
2021
medline:
22
12
2021
Statut:
epublish
Résumé
To investigate if epigenome of sperm cells could be dynamically affected by nutrition. We assessed 40 healthy volunteers with different dietary habits and collected their demographic characteristics, as well as clinical and anthropometric parameters. We compared methylation profiles in sperm quantified by bisulfite pyrosequencing, at promoter-associated CpG sites of genes involved in metabolism including fat mass and obesity-associated ( Higher DNA methylation levels were detected in the sperm of vegan at Although limited by the small number of investigated cases, our data provide insight into the role of diet on sperm DNA methylation in genes involved in metabolism.
Identifiants
pubmed: 33767672
doi: 10.3389/fendo.2021.633943
pmc: PMC7985526
doi:
Substances chimiques
MC4R protein, human
0
Receptor, Melanocortin, Type 4
0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
633943Informations de copyright
Copyright © 2021 Franzago, Sabovic, Franchi, De Santo, Di Nisio, Luddi, Piomboni, Vitacolonna, Stuppia and Foresta.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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