Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
ISSN: 1530-0366
Titre abrégé: Genet Med
Pays: United States
ID NLM: 9815831
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
28
09
2020
accepted:
02
02
2021
revised:
01
02
2021
pubmed:
31
3
2021
medline:
13
8
2021
entrez:
30
3
2021
Statut:
ppublish
Résumé
A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions. The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation. Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression. IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers.
Identifiants
pubmed: 33782552
doi: 10.1038/s41436-021-01118-9
pii: S1098-3600(21)05026-7
pmc: PMC8263480
mid: NIHMS1689965
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Types de publication
Journal Article
Pragmatic Clinical Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1191Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG007269
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG007253
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK107864
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010232
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010248
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010245
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010225
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010231
Pays : United States
Investigateurs
Aisha Montgomery
(A)
Heather Kitzman
(H)
Azita Sadeghpour
(A)
Deepak Voora
(D)
Geoffrey S Ginsburg
(GS)
Hrishikesh Chakraborty
(H)
Kady-Ann Steen-Burrell
(KA)
Lori A Orlando
(LA)
Nancy Garrett-Mead
(N)
Nina Sperber
(N)
R Ryanne Wu
(RR)
Tejinder Rakhra-Burris
(T)
Wanda Parker
(W)
Michael T Eadon
(MT)
Paul Dexter
(P)
Sheryl Lynch
(S)
Todd Skaar
(T)
Victoria Pratt
(V)
Beth Nauman
(B)
Erica Johnson
(E)
Bart Ferket
(B)
Carol R Horowitz
(CR)
Diane Hauser
(D)
Joseph Kannry
(J)
Michelle Ramos
(M)
Mart Ferket
(M)
Nandini Shroff
(N)
Neil Calman
(N)
Sabrina Clermont
(S)
Saskia Shuman
(S)
Rajbir Singh
(R)
Ebony Madden
(E)
Natalie Kucher
(N)
Simona Volpi
(S)
Kathryn Blake
(K)
Benjamin Quang Duong
(BQ)
Colette Free
(C)
Lindsay Hines
(L)
Joseph Roberts
(J)
Almut G Winterstein
(AG)
Amanda Elsey
(A)
Erica Elwood
(E)
Julie Johnson
(J)
Kristin Wiisanen
(K)
Larisa Cavallari
(L)
Rhonda Cooper-DeHoff
(R)
Alex Parker
(A)
Kim Vigal
(K)
Jyotsna Fuloria
(J)
Asa Revels
(A)
Cherry Beasley
(C)
Henry Ong
(H)
Josh Peterson
(J)
Kerri Cavanaugh
(K)
Sara Van Driest
(S)
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