Insomnia in adults with cystic fibrosis: strong association with anxiety/depression and impaired quality of life.
Adult
Anxiety
/ complications
Cystic Fibrosis
/ complications
Depression
/ complications
Female
France
Humans
Male
Pain
Psychiatric Status Rating Scales
Quality of Life
Respiratory Function Tests
Severity of Illness Index
Sleep
Sleep Initiation and Maintenance Disorders
/ complications
Surveys and Questionnaires
Young Adult
Anxiety-depression
Cystic fibrosis
Insomnia
Quality of life
Sleep
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
01 Apr 2021
01 Apr 2021
Historique:
received:
19
01
2021
accepted:
22
03
2021
entrez:
2
4
2021
pubmed:
3
4
2021
medline:
21
10
2021
Statut:
epublish
Résumé
While sleep disruption is a common complaint among children with cystic fibrosis (CF), only a few studies have investigated insomnia in adults. The aim of this study was to identify factors associated with insomnia in clinically stable adult CF patients. Twenty-eight CF patients (18M/10F), with a median age of 27 (22-34) (median (interquartile range) years and a median of forced expiratory volume in one second of 72 (39-93) % predicted completed questionnaires on insomnia (Insomnia Severity Index, ISI), sleep quality (PSQI), daytime sleepiness (Epworth), restless legs syndrome (IRLS), pain (NRS), anxiety/depression (HAD) and quality of life (CFQ-R 14+). Respiratory assessment data, including symptoms, sputum analysis, arterial blood gases, 6-min walking test, pulmonary function tests and polysomnographic variables, were also analyzed. Forty-three percent of patients were insomniac (ISI > 7). Compared with non-insomniac patients (ISI ≤ 7), insomniac patients had more severely impaired quality of life and a higher HAD score: median anxiety score of 9 (8-11) vs 4 (3-6) (p < 0.0001), median depression score of 7 (5-10) vs 1 (1-4) (p < 0.001), with a positive correlation between ISI and HAD anxiety/depression scores (r = 0.702/r = 0.701, respectively, p < 0.0001). Insomnia was also associated with mMRC dyspnea scale ≥ 2, restless legs syndrome, pain and lower SpO The strong association between insomnia, impaired quality of life and increased HAD score should prompt physicians to be particularly attentive to the management of anxiety and depression in adult CF patients with insomnia. On clinicaltrials.gov (NCT02924818, date of registration: October 5, 2016).
Sections du résumé
BACKGROUND
BACKGROUND
While sleep disruption is a common complaint among children with cystic fibrosis (CF), only a few studies have investigated insomnia in adults. The aim of this study was to identify factors associated with insomnia in clinically stable adult CF patients.
METHODS
METHODS
Twenty-eight CF patients (18M/10F), with a median age of 27 (22-34) (median (interquartile range) years and a median of forced expiratory volume in one second of 72 (39-93) % predicted completed questionnaires on insomnia (Insomnia Severity Index, ISI), sleep quality (PSQI), daytime sleepiness (Epworth), restless legs syndrome (IRLS), pain (NRS), anxiety/depression (HAD) and quality of life (CFQ-R 14+). Respiratory assessment data, including symptoms, sputum analysis, arterial blood gases, 6-min walking test, pulmonary function tests and polysomnographic variables, were also analyzed.
RESULTS
RESULTS
Forty-three percent of patients were insomniac (ISI > 7). Compared with non-insomniac patients (ISI ≤ 7), insomniac patients had more severely impaired quality of life and a higher HAD score: median anxiety score of 9 (8-11) vs 4 (3-6) (p < 0.0001), median depression score of 7 (5-10) vs 1 (1-4) (p < 0.001), with a positive correlation between ISI and HAD anxiety/depression scores (r = 0.702/r = 0.701, respectively, p < 0.0001). Insomnia was also associated with mMRC dyspnea scale ≥ 2, restless legs syndrome, pain and lower SpO
CONCLUSIONS
CONCLUSIONS
The strong association between insomnia, impaired quality of life and increased HAD score should prompt physicians to be particularly attentive to the management of anxiety and depression in adult CF patients with insomnia.
TRIAL REGISTRATION
BACKGROUND
On clinicaltrials.gov (NCT02924818, date of registration: October 5, 2016).
Identifiants
pubmed: 33794842
doi: 10.1186/s12890-021-01473-y
pii: 10.1186/s12890-021-01473-y
pmc: PMC8017792
doi:
Banques de données
ClinicalTrials.gov
['NCT02924818']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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