Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission.
3,4-Dihydroxyphenylacetic Acid
/ metabolism
Administration, Oral
Animals
Antidepressive Agents
/ administration & dosage
Anxiety
/ drug therapy
Behavior, Animal
/ drug effects
Biogenic Monoamines
/ metabolism
Crocus
Depression
/ drug therapy
Dopamine
/ metabolism
Homovanillic Acid
/ metabolism
Hydroxyindoleacetic Acid
/ metabolism
Male
Mice
Mice, Inbred C57BL
Phytotherapy
Plant Extracts
/ administration & dosage
Serotonin
/ metabolism
Synaptic Transmission
/ drug effects
Safr’InsideTM
depressive-like behavior
monoaminergic neurotransmission
mood disorders
nutritional interventions
saffron extract
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
29
01
2021
revised:
01
03
2021
accepted:
04
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
15
5
2021
Statut:
epublish
Résumé
Depressive disorders represent a major public health concern and display a continuously rising prevalence. Importantly, a large proportion of patients develops aversive side effects and/or does not respond properly to conventional antidepressants. These issues highlight the need to identify further therapeutic strategies, including nutritional approaches using natural plant extracts with known beneficial impacts on health. In that context, growing evidence suggests that saffron could be a particularly promising candidate. This preclinical study aimed therefore to test its antidepressant-like properties in mice and to decipher the underlying mechanisms by focusing on monoaminergic neurotransmission, due to its strong implication in mood disorders. For this purpose, the behavioral and neurobiochemical impact of a saffron extract, Safr'Inside™ (6.5 mg/kg
Identifiants
pubmed: 33799507
pii: nu13030904
doi: 10.3390/nu13030904
pmc: PMC8001199
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Biogenic Monoamines
0
Plant Extracts
0
3,4-Dihydroxyphenylacetic Acid
102-32-9
Serotonin
333DO1RDJY
Hydroxyindoleacetic Acid
54-16-0
Dopamine
VTD58H1Z2X
Homovanillic Acid
X77S6GMS36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Association Nationale de la Recherche et de la Technologie
ID : 2018/0592
Organisme : Institut National de la Recherche Agronomique
ID : 2200121-2494
Organisme : Activ'Inside
ID : 2200121-2494
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