Sphingosine-1-phosphate receptor 3 signaling.

Cell Proliferation Cells, Cultured Lysophospholipids Receptors, Lysosphingolipid Signal Transduction Sphingosine Sphingosine-1-Phosphate Receptors
Cancer Cardiovascular function Fibrosis Immune response Neurological function Sphingosine-1-phosohate receptor 3

Journal

Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422

Informations de publication

Date de publication:
Aug 2021
Historique:
received: 19 11 2020
revised: 18 03 2021
accepted: 29 03 2021
pubmed: 4 4 2021
medline: 22 6 2021
entrez: 3 4 2021
Statut: ppublish

Résumé

Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5. In recent years, a growing number of studies have shown that S1PR3 plays an important role in cell proliferation, differentiation, apoptosis, and migration, but its function is still controversial. This is the first comprehensive review paper about the role of S1PR3 signaling in cardiovascular function, tissue fibrosis, cancer, immune response, and neurological function. In addition, existing S1PR3 agonists and antagonists are listed at the end of the article, and we also put forward our opinion on the dispute of S1PR3 function.

Identifiants

DOI: 10.1016/j.cca.2021.03.025 PMID: 33811927
pubmed: 33811927
pii: S0009-8981(21)00110-8
doi: 10.1016/j.cca.2021.03.025
pii:
doi:

Substances chimiques

Lysophospholipids 0
Receptors, Lysosphingolipid 0
Sphingosine-1-Phosphate Receptors 0
Sphingosine NGZ37HRE42

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

32-39

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Qian Li (Q)

Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

Yi Li (Y)

Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

Cai Lei (C)

Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

Ying Tan (Y)

Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China.

Guanghui Yi (G)

Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China. Electronic address: ghyi6108@163.com.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Cellules › Cellules cultivées › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Lysophospholipides › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs aux lysosphingolipides › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Sphingosine › Sphingosine-1-phosphate receptor 3 signaling.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs aux lysosphingolipides › Récepteurs de la sphingosine-1-phosphate › Sphingosine-1-phosphate receptor 3 signaling.