Histone transcription regulator Slm9 is required for cytoophidium biogenesis.
CTP synthase
Cytoophidium
Schizosaccharomyces pombe
Slm9
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
20
11
2020
revised:
25
03
2021
accepted:
28
03
2021
pubmed:
5
4
2021
medline:
22
9
2021
entrez:
4
4
2021
Statut:
ppublish
Résumé
The cytoophidium, a subcellular structure composed of CTP synthase, can be observed during the division of Schizosaccharomyces pombe. Cytoophidium formation changes periodically with the cell cycle of yeast cells. Here, we find that histone chaperone Slm9 is required for the integrity of cytoophidia in fission yeast. When the slm9 gene is knocked out, we observe that morphological characteristics, the abundance of cytoophidia and the division of the yeast cells are significantly affected. Fragmented cytoophidia occur in slm9 mutant cells, a phenomenon rarely observed in wild-type cells. Our study reveals a potential link between a chromosomal regulatory factor and cytoophidium biogenesis.
Identifiants
pubmed: 33812868
pii: S0014-4827(21)00114-2
doi: 10.1016/j.yexcr.2021.112582
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Histones
0
Schizosaccharomyces pombe Proteins
0
Slm9 protein, S pombe
0
Carbon-Nitrogen Ligases
EC 6.3.-
CTP synthetase
EC 6.3.4.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112582Subventions
Organisme : Medical Research Council
ID : MC_U137788471
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12021/3
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.