The structure, function and evolution of a complete human chromosome 8.

Animals Cell Line Centromere / chemistry Chromosomes, Human, Pair 8 / chemistry DNA Methylation DNA, Satellite / genetics Epigenesis, Genetic Evolution, Molecular Female Humans Macaca mulatta / genetics Male Minisatellite Repeats / genetics Pan troglodytes / genetics Phylogeny Pongo abelii / genetics Telomere / chemistry

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
05 2021
Historique:
received: 04 09 2020
accepted: 04 03 2021
pubmed: 9 4 2021
medline: 28 5 2021
entrez: 8 4 2021
Statut: ppublish

Résumé

The complete assembly of each human chromosome is essential for understanding human biology and evolution

Identifiants

DOI: 10.1038/s41586-021-03420-7 PMID: 33828295 PMC: PMC8099727
pubmed: 33828295
doi: 10.1038/s41586-021-03420-7
pii: 10.1038/s41586-021-03420-7
pmc: PMC8099727
mid: NIHMS1696366
doi:

Substances chimiques

DNA, Satellite 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101-107

Subventions

Organisme : NHGRI NIH HHS
ID : K99 HG011041
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG011274
Pays : United States
Organisme : NHGRI NIH HHS
ID : R21 HG010548
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG010971
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG002385
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR074990
Pays : United States
Organisme : NLM NIH HHS
ID : T32 LM012419
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIGMS NIH HHS
ID : F32 GM134558
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG000035
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG010169
Pays : United States

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Auteurs

Glennis A Logsdon (GA)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0003-2396-0656

Mitchell R Vollger (MR)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0002-8651-1615

PingHsun Hsieh (P)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Yafei Mao (Y)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0002-9648-4278

Mikhail A Liskovykh (MA)

Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA.

Sergey Koren (S)

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-1472-8962

Sergey Nurk (S)

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Ludovica Mercuri (L)

Department of Biology, University of Bari, Aldo Moro, Bari, Italy.
ORCID: 0000-0002-3688-4501

Philip C Dishuck (PC)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0003-2223-9787

Arang Rhie (A)

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-9809-8127

Leonardo G de Lima (LG)

Stowers Institute for Medical Research, Kansas City, MO, USA.
ORCID: 0000-0001-6340-6065

Tatiana Dvorkina (T)

Center for Algorithmic Biotechnology, Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.

David Porubsky (D)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0001-8414-8966

William T Harvey (WT)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Alla Mikheenko (A)

Center for Algorithmic Biotechnology, Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.

Andrey V Bzikadze (AV)

Graduate Program in Bioinformatics and Systems Biology, University of California, San Diego, San Diego, CA, USA.

Milinn Kremitzki (M)

McDonnell Genome Institute, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.

Tina A Graves-Lindsay (TA)

McDonnell Genome Institute, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA.

Chirag Jain (C)

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Kendra Hoekzema (K)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Shwetha C Murali (SC)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.

Katherine M Munson (KM)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
ORCID: 0000-0001-8413-6498

Carl Baker (C)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Melanie Sorensen (M)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Alexandra M Lewis (AM)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

Urvashi Surti (U)

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.

Jennifer L Gerton (JL)

Stowers Institute for Medical Research, Kansas City, MO, USA.
ORCID: 0000-0003-0743-3637

Vladimir Larionov (V)

Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA.

Mario Ventura (M)

Department of Biology, University of Bari, Aldo Moro, Bari, Italy.
ORCID: 0000-0001-7762-8777

Karen H Miga (KH)

Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA.
ORCID: 0000-0002-3670-4507

Adam M Phillippy (AM)

Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-2983-8934

Evan E Eichler (EE)

Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA. eee@gs.washington.edu.
Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. eee@gs.washington.edu.
ORCID: 0000-0002-8246-4014

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The structure, function and evolution of a...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Centromère › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 6-12 et X › Chromosomes humains de la paire 8 › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › ADN satellite › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › The structure, function and evolution of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The structure, function and evolution of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Répétitions minisatellites › The structure, function and evolution of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Pan troglodytes › The structure, function and evolution of a...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › The structure, function and evolution of a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Pongo › Pongo abelii › The structure, function and evolution of a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › The structure, function and evolution of a...