Fatal Pandoraea nosoerga infection after combined liver-lung transplantation for cystic fibrosis: a recontamination by the pre-transplantation strain.
Adult
Anti-Bacterial Agents
/ therapeutic use
Burkholderiaceae
/ genetics
Cystic Fibrosis
/ surgery
Fatal Outcome
Female
Gram-Negative Bacterial Infections
/ drug therapy
Humans
Liver
/ surgery
Liver Transplantation
/ adverse effects
Lung
/ microbiology
Lung Transplantation
/ adverse effects
Postoperative Complications
/ drug therapy
Comparative genomic
Cystic fibrosis
Drug repurposing
Extensively drug-resistant bacteria
Pandoraea
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
25
09
2020
accepted:
21
03
2021
pubmed:
9
4
2021
medline:
24
12
2021
entrez:
8
4
2021
Statut:
ppublish
Résumé
A 26-year-old girl with a longstanding colonization by Pandoraea nosoerga underwent liver-lung transplantation for cystic fibrosis (CF) in 2018. Her brother also suffering from CF was also colonized by P. nosoerga. Despite appropriate perioperative antibiotic therapy, she had post-transplant bacteremic pneumonia caused by extensively drug-resistant P. nosoerga. Drug repurposing was used to optimize treatment options. The cause of post-transplant contamination was studied by comparative whole-genome sequencing including pre- and post-transplant strains and her brother's strains. Post-transplant contamination appeared to be due to her own pre-transplant strain, emphasizing the urgent need to study and implement effective decontamination protocols before transplantation.
Identifiants
pubmed: 33830365
doi: 10.1007/s10096-021-04235-0
pii: 10.1007/s10096-021-04235-0
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2403-2406Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Green H, Jones AM (2015) The microbiome and emerging pathogens in cystic fibrosis and non-cystic fibrosis bronchiectasis. Semin Respir Crit Care Med 36:225–235. https://doi.org/10.1055/s-0035-1546752
doi: 10.1055/s-0035-1546752
pubmed: 25826590
Snell G, Reed A, Stern M, Hadjiliadis D (2017) The evolution of lung transplantation for cystic fibrosis: a 2017 update. J Cyst Fibros 16:553–564. https://doi.org/10.1016/j.jcf.2017.06.008
doi: 10.1016/j.jcf.2017.06.008
pubmed: 28711221
Dupont L (2017) Lung transplantation in cystic fibrosis patients with difficult to treat lung infections. Curr Opin Pulm Med 23:574–579. https://doi.org/10.1097/MCP.0000000000000431
doi: 10.1097/MCP.0000000000000431
pubmed: 28858970
Hadjiliadis D, Steele MP, Chaparro C, Singer LG, Waddell TK, Hutcheon MA et al (2007) Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria. J Hear Lung Transplant 26:834–838. https://doi.org/10.1016/j.healun.2007.05.018
doi: 10.1016/j.healun.2007.05.018
Chaparro C, Maurer J, Gutierrez C, Krajden M, Chan C, Winton T et al (2001) Infection with Burkholderia cepacia in cystic fibrosis: outcome following lung transplantation. Am J Respir Crit Care Med 163:43–48. https://doi.org/10.1164/ajrccm.163.1.9811076
doi: 10.1164/ajrccm.163.1.9811076
pubmed: 11208624
Nosotti M, Tarsia P, Corinna ML (2018) Infections after lung transplantation. J Thorac Dis 10:3849–3868. https://doi.org/10.21037/jtd.2018.05.204
doi: 10.21037/jtd.2018.05.204
pubmed: 30069386
pmcid: 6051843
Coiffard B, Prud’Homme E, Hraiech S, Cassir N, Le Pavec J, Kessler R et al (2020) Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation. BMC Pulm Med 20:109. https://doi.org/10.1186/s12890-020-1151-9
doi: 10.1186/s12890-020-1151-9
pubmed: 32349719
pmcid: 7191774
Rhodes KA, Schweizer HP (2016) Antibiotic resistance in Burkholderia species. Drug Resist Updat 28:82–90. https://doi.org/10.1016/j.drup.2016.07.003
doi: 10.1016/j.drup.2016.07.003
pubmed: 27620956
pmcid: 5022785
Zhang T, Price MB, Bravo N, Villarreal JA, Kueht ML, Vierling JM et al (2020) Combined lung-liver and delayed kidney transplantation for cystic fibrosis clinical approach and outcome: a case report. Transplant Proc 52:2824–2826. https://doi.org/10.1016/j.transproceed.2020.02.154
doi: 10.1016/j.transproceed.2020.02.154
pubmed: 32389488
Hadjadj L, Baron SA, Diene SM, Rolain JM (2019) How to discover new antibiotic resistance genes? Expert Rev Mol Diagn 19:349–362. https://doi.org/10.1080/14737159.2019.1592678
doi: 10.1080/14737159.2019.1592678
pubmed: 30895843
Peeters C, De Canck E, Cnockaert M, De Brandt E, Snauwaert C, Verheyde B et al (2019) Comparative genomics of Pandoraea, a genus enriched in xenobiotic biodegradation and metabolism. Front Microbiol 10:2556. https://doi.org/10.3389/fmicb.2019.02556
doi: 10.3389/fmicb.2019.02556
pubmed: 31781066
pmcid: 6851202
Peyclit L, Baron SA, Rolain J-M (2019) Drug repurposing to fight colistin and carbapenem-resistant bacteria. Front Cell Infect Microbiol 9:193. https://doi.org/10.3389/fcimb.2019.00193
doi: 10.3389/fcimb.2019.00193
pubmed: 31245302
pmcid: 6579884
Bayjanov JR, Ekkelenkamp MB, Rogers MR, Cantón R, Benaissa-Trouw BJ, Díez-Aguilar M et al (2019) Whole-genome analysis of Pandoraea species strains from cystic fibrosis patients. Future Microbiol 14:1357–1367. https://doi.org/10.2217/fmb-2019-0038
doi: 10.2217/fmb-2019-0038
pubmed: 31762328
Shah A, Pasrija C, Boulos F, Pham S, Griffith BP, Amoroso A et al (2019) Decontamination and lung transplantation of a patient with cystic fibrosis with resistant infections. Ann Thorac Surg 107:e239–e241. https://doi.org/10.1016/j.athoracsur.2018.08.058
doi: 10.1016/j.athoracsur.2018.08.058
pubmed: 30316849
Dupont C, Aujoulat F, Chiron R, Condom P, Jumas-Bilak E, Marchandin H (2017) Highly diversified Pandoraea pulmonicola population during chronic colonization in cystic fibrosis. Front Microbiol 8:1892. https://doi.org/10.3389/fmicb.2017.01892
doi: 10.3389/fmicb.2017.01892
pubmed: 29056926
pmcid: 5635052
Rolain JM, Baquero F (2016) The refusal of the Society to accept antibiotic toxicity: missing opportunities for therapy of severe infections. Clin Microbiol Infect 22:423–427. https://doi.org/10.1016/j.cmi.2016.03.026
doi: 10.1016/j.cmi.2016.03.026
pubmed: 27050666