A translational riboswitch coordinates nascent transcription-translation coupling.
5' Untranslated Regions
Binding Sites
DNA-Directed RNA Polymerases
/ metabolism
Escherichia coli
/ metabolism
Escherichia coli Proteins
/ metabolism
Gene Expression Regulation, Bacterial
/ genetics
Peptide Elongation Factors
/ metabolism
Protein Biosynthesis
/ genetics
RNA, Bacterial
/ metabolism
RNA, Messenger
/ metabolism
Ribosomes
/ genetics
Riboswitch
/ genetics
Trans-Activators
/ metabolism
Transcription Factors
/ metabolism
Transcription, Genetic
/ genetics
RNA polymerase
nascent mRNA
ribosome
transcription–translation coupling
translational riboswitch
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
entrez:
14
4
2021
pubmed:
15
4
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Bacterial messenger RNA (mRNA) synthesis by RNA polymerase (RNAP) and first-round translation by the ribosome are often coupled to regulate gene expression, yet how coupling is established and maintained is ill understood. Here, we develop biochemical and single-molecule fluorescence approaches to probe the dynamics of RNAP-ribosome interactions on an mRNA with a translational preQ
Identifiants
pubmed: 33850018
pii: 2023426118
doi: 10.1073/pnas.2023426118
pmc: PMC8072259
pii:
doi:
Substances chimiques
5' Untranslated Regions
0
Escherichia coli Proteins
0
NusG protein, E coli
0
Peptide Elongation Factors
0
RNA, Bacterial
0
RNA, Messenger
0
RfaH protein, E coli
0
Riboswitch
0
Trans-Activators
0
Transcription Factors
0
DNA-Directed RNA Polymerases
EC 2.7.7.6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM062357
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM067153
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118524
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131922
Pays : United States
Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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