A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients.

Aged Animals Base Sequence Calcium Channels / genetics Exons Female Gene Expression Humans Hypoxia / genetics Introns Male Middle Aged Mitochondria / genetics Mitochondrial Permeability Transition Pore / metabolism Mitochondrial Proton-Translocating ATPases / deficiency Mutation Myocytes, Cardiac / metabolism Oxygen / adverse effects Prospective Studies Reperfusion Injury / genetics ST Elevation Myocardial Infarction / genetics
ATP synthase PTP STEMI patients cardiovascular diseases glycine-rich domain ischemia mitochondria reperfusion injury subunit c

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
13 04 2021
Historique:
received: 24 08 2020
revised: 07 02 2021
accepted: 22 03 2021
entrez: 14 4 2021
pubmed: 15 4 2021
medline: 15 2 2022
Statut: ppublish

Résumé

Preclinical models of ischemia/reperfusion injury (RI) demonstrate the deleterious effects of permeability transition pore complex (PTPC) opening in the first minutes upon revascularization of the occluded vessel. The ATP synthase c subunit (Csub) influences PTPC activity in cells, thus impacting tissue injury. A conserved glycine-rich domain in Csub is classified as critical because, when mutated, it modifies ATP synthase properties, protein interaction with the mitochondrial calcium (Ca

Identifiants

DOI: 10.1016/j.celrep.2021.108983 PMID: 33852870
pubmed: 33852870
pii: S2211-1247(21)00297-7
doi: 10.1016/j.celrep.2021.108983
pii:
doi:

Substances chimiques

Calcium Channels 0
Mitochondrial Permeability Transition Pore 0
mitochondrial calcium uniporter 0
ATP5F1A protein, human EC 3.6.1.14
ATP5MC1 protein, human EC 3.6.3.-
Mitochondrial Proton-Translocating ATPases EC 3.6.3.-
Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108983

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests There are no competing interests.

Auteurs

Giampaolo Morciano (G)

Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy; Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.

Gaia Pedriali (G)

Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy.

Massimo Bonora (M)

Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.

Rita Pavasini (R)

Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, 44121 Ferrara, Italy.

Elisa Mikus (E)

Cardiothoracic and Vascular Department, Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy.

Simone Calvi (S)

Cardiothoracic and Vascular Department, Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy.

Matteo Bovolenta (M)

Genethon, INSERM UMR951, 1 bis, rue de l'Internationale BP60, 91002 Evry Cedex, France.

Magdalena Lebiedzinska-Arciszewska (M)

Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Mirko Pinotti (M)

Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy.

Alberto Albertini (A)

Cardiothoracic and Vascular Department, Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy.

Mariusz R Wieckowski (MR)

Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Carlotta Giorgi (C)

Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy.

Roberto Ferrari (R)

Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, 44121 Ferrara, Italy.

Lorenzo Galluzzi (L)

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université de Paris, Paris, France.

Gianluca Campo (G)

Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, 44121 Ferrara, Italy.

Paolo Pinton (P)

Maria Cecilia Hospital, GVM Care & Research, 48033 Cotignola, Ravenna, Italy; Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, Italy. Electronic address: paolo.pinton@unife.it.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Eucaryotes › Animaux › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Exons › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › A naturally occurring mutation in ATP synthase...
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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Pore de transition de perméabilité mitochondriale › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Mitochondrial Proton-Translocating ATPases › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › A naturally occurring mutation in ATP synthase...
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questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › A naturally occurring mutation in ATP synthase...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Infarctus du myocarde avec sus-décalage du segment ST › A naturally occurring mutation in ATP synthase...