Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
Adolescent
Animals
Autoantibodies
/ blood
Autoantigens
/ immunology
B-Lymphocytes
/ immunology
CD4 Antigens
/ genetics
Case-Control Studies
Child
Child, Preschool
Cross Reactions
/ immunology
Disease Models, Animal
Epitopes, T-Lymphocyte
/ immunology
Female
HLA-DQ beta-Chains
/ immunology
Humans
Infant
Influenza A Virus, H1N1 Subtype
/ immunology
Influenza Vaccines
/ adverse effects
Influenza, Human
/ immunology
Male
Mannosyltransferases
/ immunology
Mice, Transgenic
Narcolepsy
/ blood
Neuraminidase
/ immunology
T-Lymphocytes
/ immunology
Viral Proteins
/ immunology
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
received:
07
08
2019
accepted:
18
03
2021
entrez:
17
4
2021
pubmed:
18
4
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Narcolepsy type 1 (NT1) is a chronic neurological disorder having a strong association with HLA-DQB1*0602, thereby suggesting an immunological origin. Increased risk of NT1 has been reported among children or adolescents vaccinated with AS03 adjuvant-supplemented pandemic H1N1 influenza A vaccine, Pandemrix. Here we show that pediatric Pandemrix-associated NT1 patients have enhanced T-cell immunity against the viral epitopes, neuraminidase 175-189 (NA
Identifiants
pubmed: 33863907
doi: 10.1038/s41467-021-22637-8
pii: 10.1038/s41467-021-22637-8
pmc: PMC8052463
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
CD4 Antigens
0
Epitopes, T-Lymphocyte
0
HLA-DQ beta-Chains
0
HLA-DQB1 antigen
0
Influenza Vaccines
0
Viral Proteins
0
pandemrix
0
Mannosyltransferases
EC 2.4.1.-
protein O-mannosyltransferase
EC 2.4.1.109
NA protein, influenza A virus
EC 3.2.1.18
Neuraminidase
EC 3.2.1.18
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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