Molecular diagnosis in non-small-cell lung cancer: expert opinion on

Anaplastic Lymphoma Kinase / genetics Carcinoma, Non-Small-Cell Lung / diagnosis Gene Rearrangement Genetic Markers / genetics High-Throughput Nucleotide Sequencing Humans Immunohistochemistry In Situ Hybridization, Fluorescence Lung Neoplasms / diagnosis Pathology, Molecular Protein-Tyrosine Kinases / genetics Proto-Oncogene Proteins / genetics Sequence Analysis, DNA
diagnostic techniques and procedures immunohistochemistry oncogenes

Journal

Journal of clinical pathology
ISSN: 1472-4146
Titre abrégé: J Clin Pathol
Pays: England
ID NLM: 0376601

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 15 02 2021
revised: 22 03 2021
accepted: 24 03 2021
pubmed: 21 4 2021
medline: 3 3 2022
entrez: 20 4 2021
Statut: ppublish

Résumé

The effectiveness of targeted therapies with tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC) depends on the accurate determination of the genomic status of the tumour. For this reason, molecular analyses to detect genetic rearrangements in some genes (ie,

Identifiants

DOI: 10.1136/jclinpath-2021-207490 PMID: 33875457 PMC: PMC8862096
pubmed: 33875457
pii: jclinpath-2021-207490
doi: 10.1136/jclinpath-2021-207490
pmc: PMC8862096
doi:

Substances chimiques

Genetic Markers 0
Proto-Oncogene Proteins 0
ALK protein, human EC 2.7.10.1
Anaplastic Lymphoma Kinase EC 2.7.10.1
Protein-Tyrosine Kinases EC 2.7.10.1
ROS1 protein, human EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

145-153

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

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Auteurs

Esther Conde (E)

Department of Pathology and Laboratory of Therapeutic Targets & CIBERONC, HM Hospitales, Madrid, Spain econde@hmhospitales.com.
ORCID: 0000-0002-0914-0988

Federico Rojo (F)

Department of Pathology, Hospital Universitario Fundacion Jiménez Díaz, Madrid, Spain.

Javier Gómez (J)

Department of Pathology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain.
Instituto de Investigación Sanitaria Valdecilla IDIVAL, Universidad de Cantabria, Santander, Cantabria, Spain.

Ana Belén Enguita (AB)

Department of Pathology, Clínica Dermatológica Internacional, Madrid, Spain.

Ihab Abdulkader (I)

Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Galicia, Spain.

Ana González (A)

Department of Pathology, Hospital Álvaro Cunqueiro, Vigo, Spain.

Dolores Lozano (D)

Department of Pathology, Clinica Universidad de Navarra, Pamplona, Navarra, Spain.

Nuria Mancheño (N)

Department of Pathology, La Fe University and Polytechnic Hospital, Valencia, Comunidad Valenciana, Spain.

Clara Salas (C)

Department of Pathology, Hospital Universitario Puerta del Hierro Majadahonda, Majadahonda, Madrid, Spain.

Marta Salido (M)

Department of Pathology, Hospital del Mar, Barcelona, Spain.

Eduardo Salido-Ruiz (E)

Department of Pathology, Hospital Universitario de Canarias, La Laguna, Canarias, Spain.

Enrique de Álava (E)

Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Kinase du lymphome anaplasique › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Phénomènes génétiques › Réarrangement des gènes › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Marqueurs génétiques › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Hybridation in situ › Hybridation fluorescente in situ › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Professions de santé › Médecine › Anatomopathologie › Anatomopathologie moléculaire › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Molecular diagnosis in non-small-cell lung...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Molecular diagnosis in non-small-cell lung...