Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Aged
Body Composition
Dietary Supplements
Double-Blind Method
Female
Humans
Insulin
/ administration & dosage
Insulin Resistance
Middle Aged
Mitochondria, Muscle
/ metabolism
Muscle, Skeletal
/ metabolism
NAD
/ blood
Nicotinamide Mononucleotide
/ administration & dosage
Obesity
/ metabolism
Overweight
/ metabolism
Postmenopause
Prediabetic State
/ metabolism
RNA-Seq
Signal Transduction
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
27
09
2020
accepted:
08
04
2021
pubmed:
24
4
2021
medline:
22
6
2021
entrez:
23
4
2021
Statut:
ppublish
Résumé
In rodents, obesity and aging impair nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 33888596
pii: science.abe9985
doi: 10.1126/science.abe9985
pmc: PMC8550608
mid: NIHMS1747752
doi:
Substances chimiques
Insulin
0
NAD
0U46U6E8UK
Nicotinamide Mononucleotide
1094-61-7
Banques de données
ClinicalTrials.gov
['NCT03151239']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1224-1229Subventions
Organisme : NIA NIH HHS
ID : R01 AG037457
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK056341
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104995
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047902
Pays : United States
Organisme : NIH HHS
ID : S10 OD026929
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020579
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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