Synthetic high-density lipoprotein nanoparticles: Good things in small packages.
Chemical burn
Cholesterol
Cornea
Eye drop
Inflammation
Lipoprotein
Nanotechnology
Wound healing
microRNA
Journal
The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
12
11
2020
revised:
26
01
2021
accepted:
06
03
2021
pubmed:
25
4
2021
medline:
29
9
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
Medicine has been a great beneficiary of the nanotechnology revolution. Nanotechnology involves the synthesis of functional materials with at least one size dimension between 1 and 100 nm. Advances in the field have enabled the synthesis of bio-nanoparticles that can interface with physiological systems to modulate fundamental cellular processes. One example of a diverse acting nanoparticle-based therapeutic is synthetic high-density lipoprotein (HDL) nanoparticles (NP), which have great potential for treating diseases of the ocular surface. Our group has developed a spherical HDL NP using a gold nanoparticle core. HDL NPs: (i) closely mimic the physical and chemical features of natural HDLs; (ii) contain apoA-I; (iii) bind with high-affinity to SR-B1, which is the major receptor through which HDL modulates cell cholesterol metabolism and controls the selective uptake of HDL cargo into cells; (iv) are non-toxic to cells and tissues; and (v) can be chemically engineered to display nearly any surface or core composition desired. With respect to the ocular surface, topical application of HDL NPs accelerates re-epithelization of the cornea following wounding, attenuates inflammation resulting from chemical burns and/or other stresses, and effectively delivers microRNAs with biological activity to corneal cells and tissues. HDL NPs will be the foundation of a new class of topical eye drops with great translational potential and exemplify the impact that nanoparticles can have in medicine.
Identifiants
pubmed: 33894397
pii: S1542-0124(21)00012-4
doi: 10.1016/j.jtos.2021.03.001
pmc: PMC8328934
mid: NIHMS1699597
pii:
doi:
Substances chimiques
Lipoproteins, HDL
0
Gold
7440-57-5
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-26Subventions
Organisme : NIAMS NIH HHS
ID : U01 AR071168
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY006769
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY019463
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR064144
Pays : United States
Organisme : NEI NIH HHS
ID : F32 EY006769
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028560
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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