A Low Tumor Mutational Burden and
Adult
Aged
Aged, 80 and over
Female
Gastrointestinal Neoplasms
/ drug therapy
High-Throughput Nucleotide Sequencing
Humans
Immune Checkpoint Inhibitors
/ therapeutic use
Male
Microsatellite Instability
Middle Aged
Mutation
PTEN Phosphohydrolase
/ genetics
Retrospective Studies
Treatment Outcome
Exome Sequencing
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
01
02
2021
revised:
09
03
2021
accepted:
27
04
2021
pubmed:
1
5
2021
medline:
2
4
2022
entrez:
30
4
2021
Statut:
ppublish
Résumé
This study performed a comprehensive molecular characterization of microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal (GI) tumors to elucidate predictors of response to PD-1 blockade. Forty-five patients with MSI-H/dMMR GI tumors, including gastric cancer, colorectal cancer, cholangiocarcinoma, small intestine cancer, pancreatic cancer, and duodenal cancer, receiving PD-1 blockade were analyzed. We conducted the genomic profiling of GI tumors by whole-exome sequencing or targeted next-generation sequencing. The tumor microenvironment was evaluated by transcriptomic analysis and multiplex fluorescence IHC. Patients with low tumor mutational burdens (TMBs) had lower objective response rates (ORRs; 0% vs. 48.8%) and a significantly shorter progression-free survival (PFS; 2.3 vs. 15.6 months; HR, 6.20; Low TMBs and
Identifiants
pubmed: 33926917
pii: 1078-0432.CCR-21-0401
doi: 10.1158/1078-0432.CCR-21-0401
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3714-3724Informations de copyright
©2021 American Association for Cancer Research.
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