A simple expression for the strength of selection on recombination generated by interference among mutations.
evolution of recombination
genetic architecture
genetic interference
meiosis
multilocus population genetics
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
entrez:
4
5
2021
pubmed:
5
5
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
One of the most widely cited hypotheses to explain the evolutionary maintenance of genetic recombination states that the reshuffling of genotypes at meiosis increases the efficiency of natural selection by reducing interference among selected loci. However, and despite several decades of theoretical work, a quantitative estimation of the possible selective advantage of a mutant allele increasing chromosomal map length (the average number of cross-overs at meiosis) remains difficult. This article derives a simple expression for the strength of selection acting on a modifier gene affecting the genetic map length of a whole chromosome or genome undergoing recurrent mutation. In particular, it shows that indirect selection for recombination caused by interference among mutations is proportional to [Formula: see text], where [Formula: see text] is the effective population size, U is the deleterious mutation rate per chromosome, and R is the chromosome map length. Indirect selection is relatively insensitive to the fitness effects of deleterious alleles, epistasis, or the genetic architecture of recombination rate variation and may compensate for substantial costs associated with recombination when linkage is tight. However, its effect generally stays weak in large, highly recombining populations.
Identifiants
pubmed: 33941695
pii: 2022805118
doi: 10.1073/pnas.2022805118
pmc: PMC8126786
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The author declares no competing interest.
Références
PLoS Genet. 2014 Mar 27;10(3):e1004222
pubmed: 24675740
Nature. 2006 Sep 7;443(7107):89-92
pubmed: 16957730
Evolution. 2001 Oct;55(10):1921-31
pubmed: 11761054
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2109-14
pubmed: 25646453
Nat Genet. 2015 Jul;47(7):727-735
pubmed: 25985139
Nat Genet. 2004 Nov;36(11):1203-6
pubmed: 15467721
Proc Natl Acad Sci U S A. 2021 May 11;118(19):
pubmed: 33941695
Heredity (Edinb). 2011 Dec;107(6):496-508
pubmed: 21673743
Genet Res. 1966 Dec;8(3):269-94
pubmed: 5980116
Hum Mol Genet. 2004 Nov 15;13(22):2875-83
pubmed: 15385442
Curr Biol. 2020 Apr 20;30(8):1517-1528.e6
pubmed: 32275873
Curr Biol. 2018 Apr 23;28(8):1289-1295.e4
pubmed: 29606420
Evolution. 2000 Oct;54(5):1467-79
pubmed: 11108576
Genetics. 2003 Jul;164(3):1099-118
pubmed: 12871918
Hum Mol Genet. 1996;5 Spec No:1495-504
pubmed: 8875256
Genetics. 2006 Jan;172(1):593-609
pubmed: 15944358
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109219
Science. 2008 Mar 7;319(5868):1395-8
pubmed: 18239090
Genetics. 1997 Oct;147(2):879-906
pubmed: 9335621
Mol Ecol. 2018 Jun;27(11):2477-2497
pubmed: 29676042
Nat Genet. 2005 Apr;37(4):429-34
pubmed: 15723063
Genetics. 2016 Jun;203(2):937-57
pubmed: 27075726
Philos Trans R Soc Lond B Biol Sci. 2017 Dec 19;372(1736):
pubmed: 29109228
PLoS Genet. 2009 Sep;5(9):e1000658
pubmed: 19763175
J Evol Biol. 2014 Jul;27(7):1304-22
pubmed: 24666571
Genetics. 1974 Oct;78(2):737-56
pubmed: 4448362
Genetics. 2010 Apr;184(4):1153-64
pubmed: 20139345
Genetics. 1966 Dec;54(6):1337-51
pubmed: 17248359
Genetics. 2012 Feb;190(2):295-304
pubmed: 22345605
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4838-41
pubmed: 16592864
Genetics. 2016 May;203(1):583-98
pubmed: 27029733
Nat Genet. 2014 Jan;46(1):11-6
pubmed: 24270358
Genetics. 1996 Feb;142(2):507-23
pubmed: 8852849
Genet Res. 1990 Jun;55(3):199-221
pubmed: 2394378
PLoS Genet. 2012;8(10):e1002905
pubmed: 23071443
Science. 2005 Apr 1;308(5718):107-11
pubmed: 15705809
Genetics. 2010 Apr;184(4):1095-112
pubmed: 20083613
Genetics. 2005 Apr;169(4):2353-70
pubmed: 15687279
Nature. 2010 Oct 28;467(7319):1099-103
pubmed: 20981099
Genetics. 2003 Dec;165(4):2249-58
pubmed: 14704200
Genet Res. 1993 Jun;61(3):205-24
pubmed: 8365658
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1662-9
pubmed: 25572964
Genetics. 1967 Nov;57(3):625-41
pubmed: 5583732
Genetics. 1995 Dec;141(4):1605-17
pubmed: 8601498
Genet Res. 1995 Apr;65(2):123-45
pubmed: 7605514
Trends Ecol Evol. 1998 Apr 1;13(4):145-51
pubmed: 21238235
Annu Rev Genet. 2019 Dec 3;53:19-44
pubmed: 31430178
Genetics. 1993 Aug;134(4):1289-303
pubmed: 8375663
Evolution. 2008 Feb;62(2):276-94
pubmed: 18067567
Genetics. 2006 Jul;173(3):1793-811
pubmed: 16702422
Am Nat. 2009 Jul;174 Suppl 1:S79-94
pubmed: 19476412
Hum Mol Genet. 2007 Dec 1;16(23):2870-9
pubmed: 17728321
Genetics. 2008 May;179(1):621-6
pubmed: 18493076
Trends Genet. 2017 May;33(5):364-374
pubmed: 28359582
Nat Rev Genet. 2002 Apr;3(4):252-61
pubmed: 11967550