Divergent On-DNA Transformations from DNA-Linked Piperidones.

DNA / chemistry Piperidones / chemistry

Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
18 02 2022
Historique:
pubmed: 8 5 2021
medline: 22 2 2022
entrez: 7 5 2021
Statut: ppublish

Résumé

A group of highly efficient and divergent transformations for constructing multiple DNA-linked chemotypes based on a piperidone core were successfully developed. We reported the first procedure for the synthesis of a DNA-conjugated piperidine intermediate under basic conditions. Subsequently, this substructure was subjected to additional reactions to generate several privileged scaffolds, including 4-aminopiperidine, fused [1,2,4]triazolo[1,5-

Identifiants

DOI: 10.1021/acs.joc.1c00670 PMID: 33960188
pubmed: 33960188
doi: 10.1021/acs.joc.1c00670
doi:

Substances chimiques

Piperidones 0
DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1971-1976

Auteurs

Xing Ling (X)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.

Weiwei Lu (W)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.

Lin Miao (L)

University of Nottingham Ningbo China, 199 Taikang East Road, Ningbo, Zhejiang 315100, P. R. China.

Lisa A Marcaurelle (LA)

GlaxoSmithKline, ELT/NCE Molecular Discovery, Medicinal Science & Technology, 200 Cambridge Park Drive, Cambridge, Massachusetts 02410, United States.

Xuan Wang (X)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.

Yun Ding (Y)

GlaxoSmithKline, ELT/NCE Molecular Discovery, Medicinal Science & Technology, 200 Cambridge Park Drive, Cambridge, Massachusetts 02410, United States.
ORCID: 0000-0002-9650-9332

Xiaojie Lu (X)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China.
University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China.
ORCID: 0000-0002-3600-288X

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Divergent On-DNA Transformations from...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Pipéridones › Divergent On-DNA Transformations from...