Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs.

Base Sequence DNA Plicamycin / pharmacology Transcription Factors

Journal

Structure (London, England : 1993)
ISSN: 1878-4186
Titre abrégé: Structure
Pays: United States
ID NLM: 101087697

Informations de publication

Date de publication:
06 05 2021
Historique:
entrez: 7 5 2021
pubmed: 8 5 2021
medline: 1 6 2021
Statut: ppublish

Résumé

Fusion products with the ETS family of transcription factors play critical roles in the etiology of several cancers. In this issue of Structure, Hou et al. (2020) provide insight into allosteric mechanisms by which mithramycin and its analogs perturb protein-DNA interactions in higher-order complexes at a DNA enhancer site.

Identifiants

DOI: 10.1016/j.str.2021.03.010 PMID: 33961789
pubmed: 33961789
pii: S0969-2126(21)00083-6
doi: 10.1016/j.str.2021.03.010
pii:
doi:

Substances chimiques

Transcription Factors 0
DNA 9007-49-2
Plicamycin NIJ123W41V

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

401-403

Subventions

Organisme : NCI NIH HHS
ID : HHSN261200800001E
Pays : United States

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Girma M Woldemichael (GM)

Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Barry R O'Keefe (BR)

Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: okeefeba@mail.nih.gov.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence nucléotidique › Insight into mithramycin disruption of ETS...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Insight into mithramycin disruption of ETS...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Mithramycine › Insight into mithramycin disruption of ETS...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Insight into mithramycin disruption of ETS...