Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner.

Alpha-Globulins / genetics Animals Apoptosis Brain-Derived Neurotrophic Factor / physiology Caveolin 1 / deficiency DNA, Complementary / genetics Dependovirus / genetics Focal Adhesion Kinase 1 / physiology Gene Knockdown Techniques Genes, Reporter Genes, Synthetic Genetic Therapy Genetic Vectors / therapeutic use Glaucoma / metabolism Integrin beta1 / physiology Intraocular Pressure Intravitreal Injections Membrane Glycoproteins / physiology Mice Mice, Inbred C57BL Mice, Knockout Promoter Regions, Genetic Protein Tyrosine Phosphatase, Non-Receptor Type 11 / antagonists & inhibitors Protein-Tyrosine Kinases / physiology Retina / pathology Up-Regulation
Caveolin Glaucoma Retinal Ganglion cells, Shp2 phosphatase TrkB.

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2021
Historique:
received: 04 11 2020
accepted: 20 02 2021
entrez: 17 5 2021
pubmed: 18 5 2021
medline: 29 7 2021
Statut: epublish

Résumé

SH2 domain containing tyrosine phosphatase 2 (Shp2; PTPN11) regulates several intracellular pathways downstream of multiple growth factor receptors. Our studies implicate that Shp2 interacts with Caveolin-1 (Cav-1) protein in retinal ganglion cells (RGCs) and negatively regulates BDNF/TrkB signaling. This study aimed to investigate the mechanisms underlying the protective effects of shp2 silencing in the RGCs in glaucomatous conditions.

Identifiants

DOI: 10.7150/thno.55472 PMID: 33995651 PMC: PMC8120201
pubmed: 33995651
doi: 10.7150/thno.55472
pii: thnov11p6154
pmc: PMC8120201
doi:

Substances chimiques

Alpha-Globulins 0
Bdnf protein, mouse 0
Brain-Derived Neurotrophic Factor 0
Caveolin 1 0
DNA, Complementary 0
Integrin beta1 0
Membrane Glycoproteins 0
chorionic alpha(2)-microglobulin 0
Ntrk2 protein, mouse EC 2.7.10.1
Protein-Tyrosine Kinases EC 2.7.10.1
Focal Adhesion Kinase 1 EC 2.7.10.2
Ptk2 protein, mouse EC 2.7.10.2
Protein Tyrosine Phosphatase, Non-Receptor Type 11 EC 3.1.3.48
Ptpn11 protein, mouse EC 3.1.3.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6154-6172

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Références

J Biol Chem. 2001 Mar 16;276(11):8094-103
pubmed: 11094059
Mol Vis. 2011;17:2878-88
pubmed: 22128235
Neuron. 2002 Feb 28;33(5):689-702
pubmed: 11879647
PLoS One. 2012;7(11):e49830
pubmed: 23166779
J Cell Sci. 2008 Jul 15;121(Pt 14):2360-71
pubmed: 18577581
Nat Rev Mol Cell Biol. 2007 Mar;8(3):185-94
pubmed: 17318224
Biochim Biophys Acta. 2012 Nov;1822(11):1643-9
pubmed: 22878065
CNS Neurol Disord Drug Targets. 2013 Aug;12(5):665-79
pubmed: 23469842
Exp Eye Res. 2011 Nov;93(5):599-606
pubmed: 21824472
EMBO J. 2005 Jan 26;24(2):305-14
pubmed: 15650750
J Neurosci. 2002 May 15;22(10):3977-86
pubmed: 12019317
Histol Histopathol. 2010 Feb;25(2):237-58
pubmed: 20017110
Mol Vis. 2007 Jun 15;13:881-6
pubmed: 17615539
EMBO Rep. 2010 Nov;11(11):861-7
pubmed: 20890309
Dev Biol. 1996 Nov 25;180(1):82-96
pubmed: 8948576
Clin Exp Ophthalmol. 2019 Jan;47(1):88-105
pubmed: 29900639
Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1363-72
pubmed: 23032687
Mol Neurobiol. 2019 Sep;56(9):6017-6034
pubmed: 30707393
Brain Res. 2005 Sep 28;1057(1-2):17-28
pubmed: 16139821
J Immunol. 2003 Dec 1;171(11):6072-9
pubmed: 14634121
Curr Opin Ophthalmol. 2007 Mar;18(2):110-4
pubmed: 17301611
Mol Cell Neurosci. 2005 Mar;28(3):588-98
pubmed: 15737747
Cell Mol Neurobiol. 2020 Oct;40(7):1059-1066
pubmed: 31974905
Ophthalmol Clin North Am. 2005 Sep;18(3):383-95, vi
pubmed: 16054996
Clin Exp Ophthalmol. 2012 May-Jun;40(4):341-9
pubmed: 22356435
Biochim Biophys Acta. 2014 Sep;1842(9):1567-78
pubmed: 24942931
Mol Neurobiol. 2002 Aug;26(1):45-55
pubmed: 12392055
Exp Mol Med. 2011 Dec 31;43(12):660-8
pubmed: 21918362
Biochem Biophys Res Commun. 1995 Jun 26;211(3):950-9
pubmed: 7598727
Exp Eye Res. 2015 Dec;141:3-8
pubmed: 25753840
Exp Neurol. 2019 Apr;314:111-125
pubmed: 30703361
Adv Exp Med Biol. 2014;801:15-21
pubmed: 24664676
Behav Brain Res. 2006 Sep 15;172(1):24-32
pubmed: 16750274
Mol Cell Biol. 1999 Apr;19(4):3205-15
pubmed: 10082587
Trends Biochem Sci. 2003 Jun;28(6):284-93
pubmed: 12826400
Cell Death Dis. 2018 Sep 26;9(10):1007
pubmed: 30258047
Front Mol Neurosci. 2019 Feb 22;12:24
pubmed: 30853886
Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1473-8
pubmed: 22297498
Front Cell Neurosci. 2018 Mar 27;12:85
pubmed: 29636665
Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4357-65
pubmed: 14507880
Cancer Res. 2006 Nov 15;66(22):10805-14
pubmed: 17108117
Curr Neuropharmacol. 2018;16(7):1018-1035
pubmed: 29676228
PLoS One. 2011;6(8):e22901
pubmed: 21826216
Am J Ophthalmol. 2013 Oct;156(4):724-30
pubmed: 23932216
Neuroscience. 2009 Aug 18;162(2):375-82
pubmed: 19422885
Br J Ophthalmol. 1999 Aug;83(8):980-6
pubmed: 10413706
Int J Mol Sci. 2013 May 13;14(5):10122-42
pubmed: 23670594
J Neurochem. 1997 Sep;69(3):1014-9
pubmed: 9282923
EMBO J. 2003 May 15;22(10):2324-33
pubmed: 12743027
Nat Genet. 2010 Oct;42(10):906-9
pubmed: 20835238
FEBS Lett. 2011 Oct 20;585(20):3224-8
pubmed: 21946312
Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5732-40
pubmed: 19643960
Neuroscience. 2017 Nov 19;364:175-189
pubmed: 28947394
J Mol Neurosci. 2013 Jan;49(1):96-104
pubmed: 23054592
Development. 1995 Nov;121(11):3593-602
pubmed: 8582273
Sci Rep. 2017 Aug 21;7(1):8412
pubmed: 28827627
Acta Pharmacol Sin. 2014 Oct;35(10):1227-46
pubmed: 25220640
Brain. 2006 Apr;129(Pt 4):1014-26
pubmed: 16418178
Prog Retin Eye Res. 2012 Mar;31(2):152-81
pubmed: 22155051
Invest Ophthalmol Vis Sci. 2006 Nov;47(11):4872-80
pubmed: 17065501
Prog Retin Eye Res. 2016 Mar;51:1-40
pubmed: 26113209
Mol Vis. 2002 Jun 14;8:149-60
pubmed: 12097864
Invest Ophthalmol Vis Sci. 2005 Jan;46(1):202-13
pubmed: 15623775
Am J Pathol. 2002 Jun;160(6):2207-17
pubmed: 12057923
Hum Mol Genet. 2011 Dec 1;20(23):4707-13
pubmed: 21873608
PLoS One. 2015 May 27;10(5):e0125250
pubmed: 26018803
PLoS One. 2014 Mar 14;9(3):e91582
pubmed: 24632723
Cell Signal. 2008 Mar;20(3):453-9
pubmed: 17993263
Mol Cell Biol. 2011 Jul;31(14):2973-83
pubmed: 21576358
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2577-88
pubmed: 18296662
Ophthalmology. 2014 Nov;121(11):2081-90
pubmed: 24974815
Mol Ther. 2005 Sep;12(3):402-12
pubmed: 15975850
Gene Ther. 2012 Feb;19(2):127-36
pubmed: 21975466
Front Cell Neurosci. 2013 Jan 09;6:60
pubmed: 23316132
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
pubmed: 23341629
Invest Ophthalmol Vis Sci. 2001 Apr;42(5):966-74
pubmed: 11274073
Mol Cell Biol Res Commun. 2000 Jan;3(1):1-7
pubmed: 10683310
Invest Ophthalmol Vis Sci. 2014 Apr 17;55(5):3060-6
pubmed: 24744204
Oncogene. 2000 Jan 6;19(1):75-84
pubmed: 10644982
Mol Neurobiol. 2018 Dec;55(12):9043-9056
pubmed: 29637440
PLoS One. 2012;7(10):e48332
pubmed: 23118988
Mol Neurobiol. 2020 Sep;57(9):3759-3784
pubmed: 32578008
Neurosci Lett. 2001 Jun 8;305(2):139-42
pubmed: 11376903
Cell Mol Neurobiol. 2003 Oct;23(4-5):561-78
pubmed: 14514016
J Ophthalmol. 2020 Jul 21;2020:6138132
pubmed: 32774906
Vision Res. 2002 Jan;42(2):151-7
pubmed: 11809469
Exp Eye Res. 2011 May;92(5):377-87
pubmed: 21354138
Trends Cell Biol. 2001 Dec;11(12):504-11
pubmed: 11719057
PLoS One. 2012;7(11):e49943
pubmed: 23189174
Mol Ther. 2019 Feb 6;27(2):424-441
pubmed: 30341011
Sci Rep. 2016 Jun 14;6:27837
pubmed: 27297022
Biochimie. 2008 May;90(5):749-61
pubmed: 18261994
Angiogenesis. 2007;10(4):297-305
pubmed: 17955336
BMB Rep. 2015 Mar;48(3):184-9
pubmed: 25672415
J Vet Med Sci. 2013 Nov;75(11):1479-83
pubmed: 23856815
Ophthalmic Genet. 2018 Apr;39(2):194-199
pubmed: 29111846
Lancet Glob Health. 2017 Dec;5(12):e1221-e1234
pubmed: 29032195
Trans Am Ophthalmol Soc. 2006;104:453-77
pubmed: 17471356
Biochem Biophys Res Commun. 2014 Nov 21;454(3):381-6
pubmed: 25451258
J Cell Mol Med. 2007 Sep-Oct;11(5):969-80
pubmed: 17979878
Nat Rev Mol Cell Biol. 2013 Feb;14(2):98-112
pubmed: 23340574
Biochem Biophys Res Commun. 2009 Jul 17;385(1):6-10
pubmed: 19433062

Auteurs

Mojdeh Abbasi (M)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Vivek K Gupta (VK)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Nitin Chitranshi (N)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Veer Gupta (V)

School of Medicine, Deakin University, Melbourne, VIC, Australia.

Reza Ranjbaran (R)

Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Rashi Rajput (R)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Kanishka Pushpitha (K)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Devaraj Kb (D)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Yuyi You (Y)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Save Sight Institute, Sydney University, Sydney NSW 2000, Australia.

Ghasem Hosseini Salekdeh (GH)

Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran.
Department of Molecular Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Robert G Parton (RG)

Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, The University of Queensland, Queensland 4072, Australia.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

Mehdi Mirzaei (M)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.

Stuart L Graham (SL)

Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Save Sight Institute, Sydney University, Sydney NSW 2000, Australia.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › alpha-Globulines › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Eucaryotes › Animaux › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Cavéoline-1 › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Sondes moléculaires › Sondes d'acide nucléique › Sondes d'ADN › ADN complémentaire › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Virus › Virus à ADN › Parvoviridae › Parvovirinae › Dependovirus › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Focal adhesion kinase 1 › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes rapporteurs › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes de synthèse › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Vecteurs génétiques › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Chaines bêta des intégrines › Antigènes CD29 › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes physiologiques oculaires › Pression intraoculaire › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections oculaires › Injections intravitréennes › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › SH2 Domain-Containing Protein Tyrosine Phosphatases › Protein Tyrosine Phosphatase, Non-Receptor Type 11 › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Inner retinal injury in experimental glaucoma...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Inner retinal injury in experimental glaucoma...