Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system.
Amino Acid Sequence
Conserved Sequence
Eukaryota
/ classification
Evolution, Molecular
Gram-Negative Bacteria
/ classification
Mitochondria
/ genetics
Mitochondrial Proteins
/ classification
Models, Biological
Models, Molecular
Naegleria
/ classification
Peroxisomes
/ metabolism
Phylogeny
Protozoan Proteins
/ classification
Sequence Homology, Amino Acid
Type II Secretion Systems
/ classification
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 05 2021
19 05 2021
Historique:
received:
06
06
2018
accepted:
22
03
2021
entrez:
20
5
2021
pubmed:
21
5
2021
medline:
1
6
2021
Statut:
epublish
Résumé
The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion.
Identifiants
pubmed: 34011950
doi: 10.1038/s41467-021-23046-7
pii: 10.1038/s41467-021-23046-7
pmc: PMC8134430
doi:
Substances chimiques
Mitochondrial Proteins
0
Protozoan Proteins
0
Type II Secretion Systems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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