Screening and monitoring of the BTK
Adenine
/ analogs & derivatives
Adult
Agammaglobulinaemia Tyrosine Kinase
/ antagonists & inhibitors
Aged
Aged, 80 and over
Disease Progression
Female
High-Throughput Nucleotide Sequencing
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
/ diagnosis
Male
Middle Aged
Neoplasm Recurrence, Local
/ diagnosis
Piperidines
/ therapeutic use
Point Mutation
/ drug effects
Protein Kinase Inhibitors
/ therapeutic use
CLL
chronic lymphocytic leukemia
ibrutinib
molecular monitoring
treatment resistance
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
25
01
2021
accepted:
01
04
2021
pubmed:
22
5
2021
medline:
21
12
2021
entrez:
21
5
2021
Statut:
ppublish
Résumé
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are the predominant genetic alterations associated with secondary ibrutinib resistance. To assess the correlation between disease progression, and the emergence and temporal dynamics of the most common resistance mutation BTK
Substances chimiques
Piperidines
0
Protein Kinase Inhibitors
0
ibrutinib
1X70OSD4VX
Agammaglobulinaemia Tyrosine Kinase
EC 2.7.10.2
BTK protein, human
EC 2.7.10.2
Adenine
JAC85A2161
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
355-364Informations de copyright
© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
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