Network topology of the cognitive phenotypes of temporal lobe epilepsy.
Cognition
Graph theory
Network analysis
Phenotypes
Temporal lobe epilepsy
Journal
Cortex; a journal devoted to the study of the nervous system and behavior
ISSN: 1973-8102
Titre abrégé: Cortex
Pays: Italy
ID NLM: 0100725
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
12
11
2020
revised:
04
02
2021
accepted:
28
03
2021
pubmed:
25
5
2021
medline:
4
8
2021
entrez:
24
5
2021
Statut:
ppublish
Résumé
The neuropsychological complications of temporal lobe epilepsy are characterized by a spectrum of reproducible cognitive phenotypes that vary in the presence, type and degree of impairment. The nature of the disruptions to the neuropsychological networks that underlie these phenotypes remain to be characterized and represent the subject of this investigation. Participants included 30 healthy controls and 104 patients with temporal lobe epilepsy who fell into three cognitive phenotypes (intact, focal impairment, generalized impairment). Eighteen neuropsychological measures representing multiple cognitive domains (language, memory, executive function, visuoperception, motor speed) were examined by graph theory techniques within the control and each epilepsy cognitive phenotype group to characterize their global and local network properties. Across the control and epilepsy cognitive phenotype groups (intact to focal to generalized impairment), there was: 1) an orderly breakdown in the positive manifold reflected by a stepwise reduction of positive associations among the neuropsychological tests, 2) stepwise abnormal increases in global measures including the normalized clustering coefficient and modularity index, 3) stepwise abnormal decreases in normalized global efficiency, 4) a community structure demonstrating well organized modules within the control group while each epilepsy group showed deviations from controls, and 5) lower strength, compared to controls, across 8 nodes in the focal and generalized impairment groups compared to only 3 nodes in the no-impairment epilepsy group, pointing to the superior integration of local connections in controls. The cognitive phenotypes of temporal lobe epilepsy are characterized by orderly abnormalities in their underlying neuropsychological networks. These findings inform the network perturbations that underlie the taxonomy of cognitive abnormality in temporal lobe epilepsy and provide a model for examination of similar issues in other focal and generalized epilepsies.
Identifiants
pubmed: 34029858
pii: S0010-9452(21)00149-0
doi: 10.1016/j.cortex.2021.03.031
pmc: PMC8319135
mid: NIHMS1720719
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-65Subventions
Organisme : NINDS NIH HHS
ID : R01 NS111022
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009206
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS093650
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
PLoS One. 2007 Oct 17;2(10):e1049
pubmed: 17940613
Neuroimage Clin. 2020;27:102341
pubmed: 32707534
Neurology. 2019 Apr 23;92(17):e1957-e1968
pubmed: 30918094
Epilepsia. 2020 Jun;61(6):1211-1220
pubmed: 32363598
Trends Cogn Sci. 2004 Sep;8(9):418-25
pubmed: 15350243
Med Clin North Am. 1963 Nov;47:1647-58
pubmed: 14078168
J Intell. 2017 Apr 20;5(2):
pubmed: 31162407
PLoS One. 2015 Oct 27;10(10):e0141186
pubmed: 26505900
Cortex. 2020 Mar;124:85-96
pubmed: 31846889
J Int Neuropsychol Soc. 2014 Jul;20(6):630-41
pubmed: 24960594
Epilepsy Behav. 2020 Nov;112:107386
pubmed: 32911298
Epilepsy Behav. 2016 Oct;63:9-16
pubmed: 27532489
Front Syst Neurosci. 2010 Jun 07;4:16
pubmed: 20589099
Arch Clin Neuropsychol. 2015 Aug;30(5):359-68
pubmed: 26025230
N Engl J Med. 2000 Feb 3;342(5):314-9
pubmed: 10660394
Epilepsy Behav. 2016 Nov;64(Pt B):329-335
pubmed: 27017326
J Int Neuropsychol Soc. 2007 Jan;13(1):12-20
pubmed: 17166299
Epilepsy Res. 2019 Jul;153:68-70
pubmed: 30850259
Epilepsy Behav. 2018 Feb;79:138-145
pubmed: 29287217
Neuroimage. 2020 Jun;213:116706
pubmed: 32151761
Cortex. 2019 Aug;117:41-52
pubmed: 30927560
Epilepsy Behav. 2019 Jul;96:61-68
pubmed: 31077942
Brain Connect. 2019 Mar;9(2):174-183
pubmed: 30398367
Epilepsy Behav. 2009 Aug;15(4):445-51
pubmed: 19560403