Evolutionary history of Caulobacter toxin-antitoxin systems.
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
16
02
2021
accepted:
21
05
2021
pubmed:
29
5
2021
medline:
22
7
2021
entrez:
28
5
2021
Statut:
ppublish
Résumé
Toxin-antitoxin (TA) systems have been studied in many bacterial genera, but a clear understanding of the evolutionary trajectory of TA operons has not emerged. To address this issue, I identified 42 distinct TA operons in three genomes that represent the three branches of the Caulobacter phylogenetic tree. The location of each operon was then examined to determine if the operon was present in eight additional Caulobacter genomes. Most of the 42 TA operons were present at the same chromosomal location in genomes that represent at least two different branches of the Caulobacter phylogenetic tree. This result indicates that the chromosomal location of TA operons is conserved over evolutionary time scales. One the other hand, there were 177 instances where a TA operon was not present at an expected chromosomal location and four instances where only the antitoxin gene was present. Thus, the variable number of TA operons found in each genome appears to be due primarily to the loss of TA operons, and the addition of new TA operons to a genome was relatively rare. An additional feature of the TA operons was that they seemed to accumulate mutations faster than the adjacent genes.
Identifiants
pubmed: 34047829
doi: 10.1007/s00284-021-02549-y
pii: 10.1007/s00284-021-02549-y
doi:
Substances chimiques
Bacterial Proteins
0
Bacterial Toxins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2899-2904Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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