Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells.

Amino Acid Sequence Animals CRISPR-Cas Systems / genetics Cell Death / drug effects Chlorocebus aethiops Drug Resistance, Bacterial / drug effects Humans Membrane Proteins / chemistry Polysaccharides / biosynthesis RNA-Binding Proteins / metabolism Shiga Toxin / toxicity Vero Cells trans-Golgi Network / metabolism
CRISPR/CAS9 SYS1 Shiga toxin Vero genome-wide screening glycosphingolipid

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
06 May 2021
Historique:
received: 21 04 2021
revised: 01 05 2021
accepted: 04 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 22 6 2021
Statut: epublish

Résumé

Shiga toxin (STx) or Vero toxin is a virulence factor produced by enterohemorrhagic

Identifiants

DOI: 10.3390/ijms22094936 PMID: 34066520 PMC: PMC8124574
pubmed: 34066520
pii: ijms22094936
doi: 10.3390/ijms22094936
pmc: PMC8124574
pii:
doi:

Substances chimiques

Membrane Proteins 0
Polysaccharides 0
RNA-Binding Proteins 0
Shiga Toxin 75757-64-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Japan Society for the Promotion of Science
ID : JP17K07357
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : JP17H06417
Organisme : Japan Agency for Medical Research and Development
ID : JP19fm0208005j0103
Organisme : Japan Agency for Medical Research and Development
ID : JP20fk0108121j0201
Organisme : Japan Agency for Medical Research and Development
ID : JP19fm0208005j0102
Organisme : Japan Agency for Medical Research and Development
ID : JP20gm0910005j0006
Organisme : Mizutani Foundation for Glycoscience
ID : 160123

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Auteurs

Chisato Sakuma (C)

Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Tsuyoshi Sekizuka (T)

Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Makoto Kuroda (M)

Pathogen Genomics Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Kentaro Hanada (K)

Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

Toshiyuki Yamaji (T)

Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Glucides › Polyosides › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Entérotoxines › Shiga-toxines › Shiga-toxine › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Vero › Identification of SYS1 as a Host Factor...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Appareil de Golgi › Réseau trans-golgien › Identification of SYS1 as a Host Factor...