Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial.
1-Acylglycerophosphocholine O-Acyltransferase
/ antagonists & inhibitors
1-Alkyl-2-acetylglycerophosphocholine Esterase
/ antagonists & inhibitors
Adult
Dietary Supplements
Double-Blind Method
Enzyme Inhibitors
/ administration & dosage
Female
Humans
Male
Middle Aged
Olea
Platelet Activating Factor
/ antagonists & inhibitors
Yogurt
LpPLA2
PAF enzymes
PAF inhibitors
PAF-CPT
olive pomace
platelet-activating factor (PAF)
yogurt
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
21
04
2021
revised:
21
05
2021
accepted:
26
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
23
9
2021
Statut:
epublish
Résumé
Platelet-activating factor (PAF), a proinflammatory lipid mediator, plays a crucial role in the formation of the atherosclerotic plaque. Therefore, the inhibition of endothelium inflammation by nutraceuticals, such as PAF inhibitors, is a promising alternative for preventing cardiovascular diseases. The aim of the present study was to evaluate the impact of a new functional yogurt enriched with PAF inhibitors of natural origin from olive oil by-products on PAF metabolism. Ninety-two apparently healthy, but mainly overweight volunteers (35-65 years) were randomly allocated into three groups by block-randomization. The activities of PAF's biosynthetic and catabolic enzymes were measured, specifically two isoforms of acetyl-CoA:lyso-PAF acetyltransferase (LPCATs), cytidine 5'-diphospho-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT) and two isoforms of platelet activating factor acetylhydrolase in leucocytes (PAF-AH) and plasma (lipoprotein associated phospholipase-A
Identifiants
pubmed: 34071485
pii: biom11060801
doi: 10.3390/biom11060801
pmc: PMC8227157
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Platelet Activating Factor
0
1-Acylglycerophosphocholine O-Acyltransferase
EC 2.3.1.23
1-Alkyl-2-acetylglycerophosphocholine Esterase
EC 3.1.1.47
PLA2G7 protein, human
EC 3.1.1.47
Banques de données
ClinicalTrials.gov
['NCT02259205']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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