Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes.
AIDS Vaccines
/ immunology
Adaptation, Physiological
/ immunology
Adult
Alleles
CD4-Positive T-Lymphocytes
/ virology
CD8-Positive T-Lymphocytes
/ immunology
Cytokines
/ metabolism
Dendritic Cells
/ immunology
Epitopes, T-Lymphocyte
/ immunology
HIV Infections
/ immunology
HIV-1
/ immunology
Histocompatibility Antigens Class I
/ genetics
Humans
Kaplan-Meier Estimate
Male
Viral Load
Young Adult
CD8 T cells
HIV vaccine
HLA-I-associated HIV adaptation
MRKAd5 vaccine
STEP study
monocyte-derived dendritic cells
viral trans-infection
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
26 07 2021
26 07 2021
Historique:
pubmed:
3
6
2021
medline:
12
10
2021
entrez:
2
6
2021
Statut:
ppublish
Résumé
HIV frequently escapes CD8 T cell responses, leading to the accumulation of viral adaptations. We recently demonstrated that during chronic HIV infection, adapted epitopes can promote maturation of dendritic cells (DCs) through direct CD8 T cell interactions and lead to enhanced HIV
Identifiants
pubmed: 34076482
doi: 10.1128/JVI.00160-21
pmc: PMC8312883
doi:
Substances chimiques
AIDS Vaccines
0
Cytokines
0
Epitopes, T-Lymphocyte
0
Histocompatibility Antigens Class I
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0016021Subventions
Organisme : NIAID NIH HHS
ID : P30 AI027767
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112566
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI140829
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR048311
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068614
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068618
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : AI140829
Organisme : NIAID NIH HHS
ID : UM1 AI068635
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : AI143482
Organisme : NIAID NIH HHS
ID : R56 AI143482
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI155295
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : AI112566
Références
PLoS Pathog. 2019 Aug 9;15(8):e1007970
pubmed: 31398241
Immunity. 2016 Sep 20;45(3):656-668
pubmed: 27653601
Nature. 2017 Mar 23;543(7646):559-563
pubmed: 28289286
Clin Immunol Immunopathol. 1991 Feb;58(2):236-50
pubmed: 1824687
J Exp Med. 1999 Mar 15;189(6):991-8
pubmed: 10075982
J Infect Dis. 2010 Mar;201(5):720-9
pubmed: 20132004
N Engl J Med. 2009 Dec 3;361(23):2209-20
pubmed: 19843557
J Immunol. 2002 Apr 15;168(8):3874-80
pubmed: 11937541
Nat Med. 2009 Aug;15(8):873-5
pubmed: 19620961
J Infect Dis. 2019 Oct 8;220(10):1620-1628
pubmed: 31301135
J Exp Med. 2016 Sep 19;213(10):2049-63
pubmed: 27551154
Nat Med. 2016 Jun;22(6):606-13
pubmed: 27183217
J Immunol. 2013 Sep 1;191(5):2570-80
pubmed: 23913962
J Immunol. 1999 Mar 1;162(5):2748-53
pubmed: 10072520
J Infect Dis. 2012 Jul 15;206(2):258-66
pubmed: 22561365
Nat Med. 2009 Aug;15(8):876-8
pubmed: 19620962
Nature. 1997 Jul 17;388(6639):238
pubmed: 9230431
Nature. 1998 Mar 19;392(6673):245-52
pubmed: 9521319
J Exp Med. 1997 Jun 2;185(11):2015-23
pubmed: 9166430
J Infect Dis. 2018 Jul 13;218(4):633-644
pubmed: 29669026
Lancet HIV. 2020 Oct;7(10):e688-e698
pubmed: 33010242
J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):238-44
pubmed: 21860356
J Exp Med. 2008 Nov 24;205(12):2717-25
pubmed: 18981239
J Immunol. 2016 Apr 15;196(8):3276-86
pubmed: 26983786
PLoS One. 2011;6(11):e27944
pubmed: 22125641
J Immunol. 2007 Jan 1;178(1):219-27
pubmed: 17182558
J Immunother. 1999 May;22(3):229-36
pubmed: 10335482
Virology. 2010 Dec 5;408(1):1-13
pubmed: 20863545
PLoS Pathog. 2013 Feb;9(2):e1003195
pubmed: 23468632
N Engl J Med. 2012 Apr 5;366(14):1275-86
pubmed: 22475592
J Immunol. 2008 Nov 1;181(9):5865-74
pubmed: 18941175
Retrovirology. 2013 Apr 16;10:42
pubmed: 23590845
J Immunol. 2002 Oct 1;169(7):3574-80
pubmed: 12244147
PLoS Pathog. 2019 Sep 9;15(9):e1008011
pubmed: 31498845
Front Immunol. 2019 Oct 23;10:2485
pubmed: 31708924
Immunity. 2015 Sep 15;43(3):591-604
pubmed: 26362266
Lancet. 2008 Nov 29;372(9653):1881-1893
pubmed: 19012954
Cell. 1994 Aug 12;78(3):389-98
pubmed: 7914836
Nat Immunol. 2000 Oct;1(4):298-304
pubmed: 11017100
Nat Med. 1997 Feb;3(2):212-7
pubmed: 9018241
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651
pubmed: 20457564
Blood. 2007 Jul 1;110(1):201-10
pubmed: 17371945
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2457-65
pubmed: 22895791
Science. 1992 Jul 17;257(5068):383-7
pubmed: 1352913
J Virol. 2002 Mar;76(5):2298-305
pubmed: 11836408
Nature. 1997 Jul 17;388(6639):296-300
pubmed: 9230441
J Immunol. 2010 May 1;184(9):4625-9
pubmed: 20357255