Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior.

Dopamine Dopaminergic Neurons Glutamic Acid Nucleus Accumbens Synapses
Parkinson disease VGLUT2 VMAT2 addiction glutaminase psychostimulant schizophrenia

Journal

Frontiers in neural circuits
ISSN: 1662-5110
Titre abrégé: Front Neural Circuits
Pays: Switzerland
ID NLM: 101477940

Informations de publication

Date de publication:
2021
Historique:
received: 08 02 2021
accepted: 16 04 2021
entrez: 7 6 2021
pubmed: 8 6 2021
medline: 14 1 2022
Statut: epublish

Résumé

Discovered just over 20 years ago, dopamine neurons have the ability to cotransmit both dopamine and glutamate. Yet, the functional roles of dopamine neuron glutamate cotransmission and their implications for therapeutic use are just emerging. This review article encompasses the current body of evidence investigating the functions of dopamine neurons of the ventral midbrain that cotransmit glutamate. Since its discovery in dopamine neuron cultures, further work

Identifiants

DOI: 10.3389/fncir.2021.665386 PMID: 34093138 PMC: PMC8170480
pubmed: 34093138
doi: 10.3389/fncir.2021.665386
pmc: PMC8170480
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L
Dopamine VTD58H1Z2X

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

665386

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH117128
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018870
Pays : United States

Informations de copyright

Copyright © 2021 Eskenazi, Malave, Mingote, Yetnikoff, Ztaou, Velicu, Rayport and Chuhma.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Daniel Eskenazi (D)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

Lauren Malave (L)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

Susana Mingote (S)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.
Neuroscience Initiative, Advanced Science Research Center, Graduate Center of The City University of New York, New York, NY, United States.

Leora Yetnikoff (L)

Department of Psychology, College of Staten Island, City University of New York, Staten Island, NY, United States.
CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, New York, NY, United States.

Samira Ztaou (S)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

Vlad Velicu (V)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

Stephen Rayport (S)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

Nao Chuhma (N)

Department of Psychiatry, Columbia University, New York, NY, United States.
Department of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Dopamine Neurons That Cotransmit Glutamate,...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Dopamine Neurons That Cotransmit Glutamate,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Dopamine Neurons That Cotransmit Glutamate,...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › Dopamine Neurons That Cotransmit Glutamate,...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Dopamine Neurons That Cotransmit Glutamate,...