Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats.

Animals Apoptosis / drug effects Cell Proliferation / drug effects DNA Breaks, Double-Stranded Dentate Gyrus / drug effects Dose-Response Relationship, Drug Gene Expression Regulation Neural Stem Cells / drug effects Neurogenesis / drug effects Neuronal Plasticity / drug effects No-Observed-Adverse-Effect Level Oxidative Stress / drug effects Rats, Sprague-Dawley Receptors, Neurotransmitter / genetics Sterigmatocystin / toxicity Weaning
Genotoxicity Hippocampal neurogenesis Oxidative stress Rat Sterigmatocystin Synaptic plasticity

Journal

Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027

Informations de publication

Date de publication:
01 Oct 2021
Historique:
received: 26 04 2021
revised: 08 06 2021
accepted: 09 06 2021
pubmed: 15 6 2021
medline: 20 7 2021
entrez: 14 6 2021
Statut: ppublish

Résumé

Exposure to sterigmatocystin (STC) raises concerns on developmental neurological disorders. The present study investigated the effects of maternal oral STC exposure on postnatal hippocampal neurogenesis of offspring in rats. Dams were exposed to STC (1.7, 5.0, and 15.0 ppm in diet) from gestational day 6 until day 21 post-delivery (weaning), and offspring were maintained without STC exposure until adulthood on postnatal day (PND) 77, in accordance with OECD chemical testing guideline Test No. 426. On PND 21, 15.0-ppm STC decreased type-3 neural progenitor cell numbers in the subgranular zone (SGZ) due to suppressed proliferation. Increased γ-H2AX-immunoreactive (

Identifiants

DOI: 10.1016/j.toxlet.2021.06.006 PMID: 34126181
pubmed: 34126181
pii: S0378-4274(21)00151-X
doi: 10.1016/j.toxlet.2021.06.006
pii:
doi:

Substances chimiques

Receptors, Neurotransmitter 0
Sterigmatocystin 10048-13-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

69-83

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no declarations of interest.

Auteurs

Kazumi Takashima (K)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s195238q@st.go.tuat.ac.jp.

Kota Nakajima (K)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: knakaji@m2.tuat.ac.jp.

Saori Shimizu (S)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s161721q@st.go.tuat.ac.jp.

Ryota Ojiro (R)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s204006y@st.go.tuat.ac.jp.

Qian Tang (Q)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s202349y@st.go.tuat.ac.jp.

Hiromu Okano (H)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: okano-hiromu@m2.tuat.ac.jp.

Yasunori Takahashi (Y)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s194057s@st.me.tuat.ac.jp.

Shunsuke Ozawa (S)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: s213387q@st.go.tuat.ac.jp.

Meilan Jin (M)

Laboratory of Veterinary Pathology, College of Veterinary Medicine, Southwest University, No. 2 Tiansheng Road, BeiBei District, Chongqing, 400715, PR China. Electronic address: meilan0622@swu.edu.cn.

Tomoya Yoshinari (T)

Division of Microbiology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa, 210-9501, Japan. Electronic address: t-yoshinari@nihs.go.jp.

Toshinori Yoshida (T)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: yoshida7@cc.tuat.ac.jp.

Yoshiko Sugita-Konishi (Y)

Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo, 156-8502, Japan. Electronic address: yk205686@nodai.ac.jp.

Makoto Shibutani (M)

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan. Electronic address: mshibuta@cc.tuat.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Cassures de l'ADN › Cassures double-brin de l'ADN › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Gyrus denté › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Dose sans effet nocif observé › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Mycotoxines › Stérigmatocystine › Disruption of postnatal neurogenesis and...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Sevrage › Disruption of postnatal neurogenesis and...