Maternal fecal microbiome predicts gestational age, birth weight and neonatal growth in rural Zimbabwe.

Bacteria / classification Birth Weight Body Height Child Development Feces / microbiology Female Gestational Age High-Throughput Nucleotide Sequencing Humans Infant, Newborn Male Metagenomics / methods Mothers Pregnancy RNA, Ribosomal, 16S / genetics Randomized Controlled Trials as Topic Rural Population Sequence Analysis, DNA Zimbabwe
birth weight gestation maternal metagenome microbiome pregnancy

Journal

EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 21 12 2020
revised: 14 05 2021
accepted: 17 05 2021
pubmed: 18 6 2021
medline: 15 12 2021
entrez: 17 6 2021
Statut: ppublish

Résumé

Preterm birth and low birth weight (LBW) affect one in ten and one in seven livebirths, respectively, primarily in low-income and middle-income countries (LMIC) and are major predictors of poor child health outcomes. However, both have been recalcitrant to public health intervention. The maternal intestinal microbiome may undergo substantial changes during pregnancy and may influence fetal and neonatal health in LMIC populations. Within a subgroup of 207 mothers and infants enrolled in the SHINE trial in rural Zimbabwe, we performed shotgun metagenomics on 351 fecal specimens provided during pregnancy and at 1-month post-partum to investigate the relationship between the pregnancy gut microbiome and infant gestational age, birth weight, 1-month length-, and weight-for-age z-scores using extreme gradient boosting machines. Pregnancy gut microbiome taxa and metabolic functions predicted birth weight and WAZ at 1 month more accurately than gestational age and LAZ. Blastoscystis sp, Brachyspira sp and Treponeme carriage were high compared to Western populations. Resistant starch-degraders were important predictors of birth outcomes. Microbiome capacity for environmental sensing, vitamin B metabolism, and signalling predicted increased infant birth weight and neonatal growth; while functions involved in biofilm formation in response to nutrient starvation predicted reduced birth weight and growth. The pregnancy gut microbiome in rural Zimbabwe is characterized by resistant starch-degraders and may be an important metabolic target to improve birth weight. Bill and Melinda Gates Foundation, UK Department for International Development, Wellcome Trust, Swiss Agency for Development and Cooperation, US National Institutes of Health, and UNICEF.

Sections du résumé

BACKGROUND BACKGROUND
Preterm birth and low birth weight (LBW) affect one in ten and one in seven livebirths, respectively, primarily in low-income and middle-income countries (LMIC) and are major predictors of poor child health outcomes. However, both have been recalcitrant to public health intervention. The maternal intestinal microbiome may undergo substantial changes during pregnancy and may influence fetal and neonatal health in LMIC populations.
METHODS METHODS
Within a subgroup of 207 mothers and infants enrolled in the SHINE trial in rural Zimbabwe, we performed shotgun metagenomics on 351 fecal specimens provided during pregnancy and at 1-month post-partum to investigate the relationship between the pregnancy gut microbiome and infant gestational age, birth weight, 1-month length-, and weight-for-age z-scores using extreme gradient boosting machines.
FINDINGS RESULTS
Pregnancy gut microbiome taxa and metabolic functions predicted birth weight and WAZ at 1 month more accurately than gestational age and LAZ. Blastoscystis sp, Brachyspira sp and Treponeme carriage were high compared to Western populations. Resistant starch-degraders were important predictors of birth outcomes. Microbiome capacity for environmental sensing, vitamin B metabolism, and signalling predicted increased infant birth weight and neonatal growth; while functions involved in biofilm formation in response to nutrient starvation predicted reduced birth weight and growth.
INTERPRETATION CONCLUSIONS
The pregnancy gut microbiome in rural Zimbabwe is characterized by resistant starch-degraders and may be an important metabolic target to improve birth weight.
FUNDING BACKGROUND
Bill and Melinda Gates Foundation, UK Department for International Development, Wellcome Trust, Swiss Agency for Development and Cooperation, US National Institutes of Health, and UNICEF.

Identifiants

DOI: 10.1016/j.ebiom.2021.103421 PMID: 34139432 PMC: PMC8217692
pubmed: 34139432
pii: S2352-3964(21)00214-0
doi: 10.1016/j.ebiom.2021.103421
pmc: PMC8217692
pii:
doi:

Substances chimiques

RNA, Ribosomal, 16S 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103421

Subventions

Organisme : Wellcome Trust
ID : 206455/Z/17/Z
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None.

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Auteurs

Ethan K Gough (EK)

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: amee.manges@ubc.ca.

Thaddeus J Edens (TJ)

Devil's Staircase Consulting, West Vancouver, British Columbia, Canada.

Hyun Min Geum (HM)

School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Iman Baharmand (I)

School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Sandeep K Gill (SK)

School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Ruairi C Robertson (RC)

Blizard Institute, Queen Mary University of London, London, UK.

Kuda Mutasa (K)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Robert Ntozini (R)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Laura E Smith (LE)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of Population Medicine and Diagnostics, Cornell University, Ithaca, NY, USA.

Bernard Chasekwa (B)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Florence D Majo (FD)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Naume V Tavengwa (NV)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Batsirai Mutasa (B)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Freddy Francis (F)

Department of Experimental Medicine, University of British Columbia, Canada.

Lynnea Carr (L)

Department of Microbiology and Immunology, University of British Columbia, Canada.

Joice Tome (J)

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Rebecca J Stoltzfus (RJ)

Goshen College, Goshen, Indiana, USA.

Lawrence H Moulton (LH)

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Andrew J Prendergast (AJ)

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Blizard Institute, Queen Mary University of London, London, UK; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

Jean H Humphrey (JH)

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Blizard Institute, Queen Mary University of London, London, UK.

Amee R Manges (AR)

School of Population and Public Health, University of British Columbia, Vancouver, Canada; British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.

Shine Trial Team (ST)

Members of the SHINE Trial team who are not named authors are listed in https://academic.oup.com/cid/article/61/suppl_7/S685/358186.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Poids de naissance › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Taille › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Développement humain › Développement de l'enfant › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Âge gestationnel › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Métagénomique › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Personnes › Parents › Mères › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN ribosomique › ARN ribosomique 16S › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Caractéristiques de la population › Population › Population rurale › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Maternal fecal microbiome predicts gestational...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique australe › Zimbabwe › Maternal fecal microbiome predicts gestational...