Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments.

Acetophenones / chemistry Acetylcholine / analogs & derivatives Animals Cholinesterase Inhibitors / chemistry Hippocampus / drug effects Memory Disorders / chemically induced Mice Paraoxon / toxicity
Acetylcholinesterase Neuroprotection Organophosphorus Slow-binding inhibitor Trifluoroketone

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
25 Aug 2021
Historique:
received: 29 01 2021
revised: 18 05 2021
accepted: 15 06 2021
pubmed: 21 6 2021
medline: 3 8 2021
entrez: 20 6 2021
Statut: ppublish

Résumé

m-(Tert-butyl) trifluoroacetophenone (TFK), a slow-binding inhibitor of acetylcholinesterase (AChE), a transition state analog of acetylcholine, was investigated as a potential neuroprotectant of central and peripheral AChE against organophosphate paraoxon (POX) toxicity. Acute toxicity and pharmacological effects of TFK were investigated on mice and rats. Intraperitoneal administered TFK has low acute toxicity in mice (LD

Identifiants

DOI: 10.1016/j.cbi.2021.109558 PMID: 34147486
pubmed: 34147486
pii: S0009-2797(21)00196-4
doi: 10.1016/j.cbi.2021.109558
pii:
doi:

Substances chimiques

3-(tert-butyl)trifluoroacetophenone 0
Acetophenones 0
Cholinesterase Inhibitors 0
Acetylcholine N9YNS0M02X
Paraoxon Q9CX8P80JW

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109558

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Irina Zueva (I)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov Str., 8, Kazan, 420088, Russian Federation.

Oksana Lenina (O)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov Str., 8, Kazan, 420088, Russian Federation.

Ramilya Kayumova (R)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov Str., 8, Kazan, 420088, Russian Federation.

Konstantin Petrov (K)

Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences", Arbuzov Str., 8, Kazan, 420088, Russian Federation; Kazan Federal University, Neuropharmacology Laboratory, Kremlevskaya Str 18, Kazan, 480002, Russian Federation.

Patrick Masson (P)

Kazan Federal University, Neuropharmacology Laboratory, Kremlevskaya Str 18, Kazan, 480002, Russian Federation. Electronic address: pym.masson@free.fr.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Cétones › Acétophénones › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Eucaryotes › Animaux › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protective effects of m-(tert-butyl)...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Paraoxon › Protective effects of m-(tert-butyl)...