Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction.
Adolescent
Adult
Air Pollutants
/ analysis
Air Pollution, Indoor
/ analysis
Cooking
Ethanol
Female
Fetal Development
Fetal Growth Retardation
Fetus
/ diagnostic imaging
Housing
Humans
Kerosene
Maternal Exposure
Maternal-Fetal Exchange
Nigeria
Particulate Matter
/ analysis
Pregnancy
Ultrasonography, Prenatal
Wood
Young Adult
Fetal growth
Household air pollution
Intrauterine growth restriction
Nigeria
Pregnant women
Ultrasound measurement
Journal
Environmental health : a global access science source
ISSN: 1476-069X
Titre abrégé: Environ Health
Pays: England
ID NLM: 101147645
Informations de publication
Date de publication:
23 06 2021
23 06 2021
Historique:
received:
05
01
2021
accepted:
07
06
2021
entrez:
30
6
2021
pubmed:
1
7
2021
medline:
1
9
2021
Statut:
epublish
Résumé
Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are rare. We investigated the effect of a cookstove intervention on FBP and IUGR in a randomized controlled trial (RCT) cohort of HAP-exposed pregnant Nigerian women. We recruited 324 women early in the second trimester of pregnancy. Between 16 and 18 weeks, we randomized them to either continue cooking with firewood/kerosene (control group) or receive a CleanCook stove and ethanol fuel (intervention group). We measured fetal biparietal diameter (BPD), head circumference (HC), femur length (FL), abdominal circumference (AC) and ultrasound-estimated fetal weight (U-EFW) in the second and third trimesters. The women were clinically followed up at six regular time points during their pregnancies. Once during the women's second trimester and once during the third, we made 72-h continuous measurements of their personal exposures to particulate matter having aerodynamic diameter < 2.5 μm (PM There were no significant differences in fetal growth trajectories between the intervention and control groups. Larger studies in a setting of low ambient air pollution are required to further investigate the effect of transitioning to a cleaner fuel such as ethanol on intrauterine growth. ClinicalTrials.gov NCT02394574 ; September 2012.
Sections du résumé
BACKGROUND
Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are rare. We investigated the effect of a cookstove intervention on FBP and IUGR in a randomized controlled trial (RCT) cohort of HAP-exposed pregnant Nigerian women.
METHODS
We recruited 324 women early in the second trimester of pregnancy. Between 16 and 18 weeks, we randomized them to either continue cooking with firewood/kerosene (control group) or receive a CleanCook stove and ethanol fuel (intervention group). We measured fetal biparietal diameter (BPD), head circumference (HC), femur length (FL), abdominal circumference (AC) and ultrasound-estimated fetal weight (U-EFW) in the second and third trimesters. The women were clinically followed up at six regular time points during their pregnancies. Once during the women's second trimester and once during the third, we made 72-h continuous measurements of their personal exposures to particulate matter having aerodynamic diameter < 2.5 μm (PM
RESULTS
There were no significant differences in fetal growth trajectories between the intervention and control groups.
CONCLUSIONS
Larger studies in a setting of low ambient air pollution are required to further investigate the effect of transitioning to a cleaner fuel such as ethanol on intrauterine growth.
TRIAL REGISTRATION
ClinicalTrials.gov NCT02394574 ; September 2012.
Identifiants
pubmed: 34187482
doi: 10.1186/s12940-021-00756-5
pii: 10.1186/s12940-021-00756-5
pmc: PMC8243629
doi:
Substances chimiques
Air Pollutants
0
Kerosene
0
Particulate Matter
0
Ethanol
3K9958V90M
Banques de données
ClinicalTrials.gov
['NCT02394574']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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