Neoantigens elicit T cell responses in breast cancer.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 06 2021
30 06 2021
Historique:
received:
13
12
2020
accepted:
26
05
2021
entrez:
1
7
2021
pubmed:
2
7
2021
medline:
6
11
2021
Statut:
epublish
Résumé
Neoantigens are tumour-specific antigens that arise from non-synonymous mutations in tumour cells. However, their effect on immune responses in the tumour microenvironment remains unclear in breast cancer. We performed whole exome and RNA sequencing of 31 fresh breast cancer tissues and neoantigen prediction from non-synonymous single nucleotide variants (nsSNVs) among exonic mutations. Neoantigen profiles were determined by predictive HLA binding affinity (IC
Identifiants
pubmed: 34193879
doi: 10.1038/s41598-021-91358-1
pii: 10.1038/s41598-021-91358-1
pmc: PMC8245657
doi:
Substances chimiques
Antigens, Neoplasm
0
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13590Références
Ann Oncol. 2015 Feb;26(2):259-71
pubmed: 25214542
Nat Rev Cancer. 2017 Apr;17(4):209-222
pubmed: 28233802
Cancer Treat Rev. 2018 Sep;69:152-163
pubmed: 30029203
Annu Rev Immunol. 2019 Apr 26;37:173-200
pubmed: 30550719
J Clin Oncol. 2014 Apr 1;32(10):1020-30
pubmed: 24590637
Trends Cancer. 2017 Nov;3(11):753-760
pubmed: 29120751
Anticancer Res. 2018 Jul;38(7):4273-4279
pubmed: 29970561
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
Nat Med. 2018 Jun;24(6):724-730
pubmed: 29867227
BMC Immunol. 2019 Jan 11;20(1):4
pubmed: 30634925
Ann Surg Oncol. 2019 Jul;26(7):2191-2199
pubmed: 30963401
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Immunogenetics. 2009 Jan;61(1):1-13
pubmed: 19002680
N Engl J Med. 2014 Dec 4;371(23):2189-2199
pubmed: 25409260
Nat Med. 2019 May;25(5):767-775
pubmed: 31011208
Nat Biotechnol. 2010 May;28(5):511-5
pubmed: 20436464
Bioinformatics. 2008 Jun 1;24(11):1397-8
pubmed: 18413329
Nat Commun. 2017 Nov 23;8(1):1738
pubmed: 29170503
Front Immunol. 2018 Jan 22;9:14
pubmed: 29403496
Cancer Res. 2017 Jun 15;77(12):3317-3324
pubmed: 28428277
Cell. 2015 Jan 15;160(1-2):48-61
pubmed: 25594174
BMC Med. 2019 May 9;17(1):90
pubmed: 31068190
N Engl J Med. 2012 Jun 28;366(26):2443-54
pubmed: 22658127
Nature. 2017 Nov 23;551(7681):512-516
pubmed: 29132146
Immunity. 1996 Jun;4(6):565-71
pubmed: 8673703
Nucleic Acids Res. 2010 Sep;38(16):e164
pubmed: 20601685
Cancer Sci. 2018 Mar;109(3):542-549
pubmed: 29288513
BMC Cancer. 2019 Mar 4;19(1):200
pubmed: 30832597
Science. 2014 May 9;344(6184):641-5
pubmed: 24812403
N Engl J Med. 2015 Oct 22;373(17):1627-39
pubmed: 26412456
Breast. 2016 Oct;29:241-50
pubmed: 27481651
Science. 2016 Mar 25;351(6280):1463-9
pubmed: 26940869
Lancet Oncol. 2017 Aug;18(8):1009-1021
pubmed: 28694034
Oncotarget. 2017 Jun 28;8(37):62029-62038
pubmed: 28977923
Cancer Immunol Res. 2017 Jul;5(7):516-523
pubmed: 28619968
Genome Res. 2014 May;24(5):743-50
pubmed: 24782321
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Breast Cancer Res. 2010;12 Suppl 2:S2
pubmed: 21050423
JAMA. 2019 Jan 22;321(3):288-300
pubmed: 30667505
N Engl J Med. 2015 Sep 24;373(13):1270-1
pubmed: 26398076
Nature. 2019 Oct;574(7780):696-701
pubmed: 31645760
Science. 2015 Apr 3;348(6230):69-74
pubmed: 25838375
JAMA Oncol. 2017 Dec 1;3(12):1707-1711
pubmed: 28750120
Oncoimmunology. 2017 Jan 6;6(2):e1278330
pubmed: 28344893
Nat Rev Cancer. 2012 Mar 22;12(4):252-64
pubmed: 22437870
Breast Cancer Res. 2014 May 20;16(3):210
pubmed: 25928070
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
Bioinformatics. 2014 Dec 1;30(23):3310-6
pubmed: 25143287
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):419-24
pubmed: 15623559