Co-Regulated Genes and Gene Clusters.
co-regulated genes
coordinated expression
gene clusters
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
11 06 2021
11 06 2021
Historique:
received:
28
05
2021
revised:
09
06
2021
accepted:
10
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
22
9
2021
Statut:
epublish
Résumé
There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with similar functions. In this aspect, they differ significantly from bacterial operons containing functionally linked genes that are not paralogs. In this review, we discuss the reasons for the existence of gene clusters in vertebrate cells and propose that clustering is necessary to ensure the possibility of selective activation of one of several similar genes.
Identifiants
pubmed: 34208174
pii: genes12060907
doi: 10.3390/genes12060907
pmc: PMC8230824
pii:
doi:
Substances chimiques
Cadherins
0
Globins
9004-22-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Nat Rev Microbiol. 2005 Dec;3(12):937-47
pubmed: 16322742
Nature. 1998 Jan 15;391(6664):225, 227-8
pubmed: 9440682
Blood. 2009 Nov 5;114(19):4253-60
pubmed: 19696202
Biochim Biophys Acta. 2013 Sep;1834(9):1801-12
pubmed: 23360762
Comp Biochem Physiol Part D Genomics Proteomics. 2021 Mar;37:100759
pubmed: 33202310
Brief Bioinform. 2021 May 20;22(3):
pubmed: 32793986
Trends Plant Sci. 2014 Jul;19(7):447-59
pubmed: 24582794
Nucleic Acids Res. 2021 Feb 22;49(3):1383-1396
pubmed: 33476375
Nat Genet. 2010 Jan;42(1):53-61
pubmed: 20010836
Cell. 1980 Sep;21(2):555-64
pubmed: 7407927
Dev Suppl. 1994;:125-33
pubmed: 7579513
Mol Biol Evol. 2006 Sep;23(9):1715-23
pubmed: 16757654
Dev Biol. 2012 Jun 15;366(2):185-94
pubmed: 22537494
Genomics. 2007 May;89(5):580-7
pubmed: 17369017
Science. 2009 Jun 5;324(5932):1320-3
pubmed: 19498168
Mol Biol Evol. 2009 Apr;26(4):783-99
pubmed: 19174480
Epigenetics Chromatin. 2017 Jul 11;10(1):35
pubmed: 28693562
Genome Biol Evol. 2009 Nov 25;1:479-93
pubmed: 20333216
Cell. 1987 Dec 24;51(6):975-85
pubmed: 3690667
Mol Cell Biol. 1992 Apr;12(4):1561-7
pubmed: 1549112
Mol Cell Biol. 2005 Oct;25(20):8765-78
pubmed: 16199858
Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31231-31241
pubmed: 33229569
Int Rev Cytol. 2003;226:63-125
pubmed: 12921236
Mol Biol Evol. 2012 Jan;29(1):303-12
pubmed: 21965344
Nat Rev Genet. 2004 Apr;5(4):299-310
pubmed: 15131653
Nucleic Acids Res. 2008 Aug;36(14):4521-8
pubmed: 18586828
Science. 2018 Jul 27;361(6400):
pubmed: 29930091
Bioessays. 2019 Jan;41(1):e1800164
pubmed: 30500078
Curr Opin Genet Dev. 2021 Apr;67:18-24
pubmed: 33221670
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14144-9
pubmed: 15381776
Cell. 1980 Sep;21(2):565-73
pubmed: 6250724
Biochemistry (Mosc). 2018 Apr;83(4):381-392
pubmed: 29626925
Nature. 2002 Jun 20;417(6891):851-4
pubmed: 12075352
Genome Res. 2004 Jan;14(1):79-89
pubmed: 14672974
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17065-70
pubmed: 16286657
J Biol Chem. 2013 Mar 22;288(12):8433-8444
pubmed: 23341446
Nucleic Acids Res. 2016 Jun 2;44(10):4651-64
pubmed: 26893355
Nucleic Acids Res. 2008 Aug;36(14):4629-40
pubmed: 18621783
Biochem Cell Biol. 2009 Oct;87(5):781-90
pubmed: 19898527
Cytogenet Genome Res. 2006;112(3-4):296-306
pubmed: 16484786
Nature. 2019 Jan;565(7740):448-453
pubmed: 30626972
Nat Genet. 2005 Jul;37(7):777-82
pubmed: 15951822
Cell. 1992 May 29;69(5):781-93
pubmed: 1591777
Chromosome Res. 2010 Dec;18(8):897-907
pubmed: 21116705
EMBO J. 1995 Apr 18;14(8):1718-26
pubmed: 7737123
Nucleic Acids Res. 2019 Dec 16;47(22):11481-11496
pubmed: 31724731
Cell. 2019 Apr 18;177(3):639-653.e15
pubmed: 30955885
Science. 2003 Dec 19;302(5653):2088-94
pubmed: 14593185
Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12472-12480
pubmed: 32409606
Int J Biochem Cell Biol. 2016 Jun;75:45-52
pubmed: 27026582
Nat Commun. 2017 Oct 12;8(1):885
pubmed: 29026079
Mol Cell. 2002 Dec;10(6):1453-65
pubmed: 12504019
Nucleic Acids Res. 2020 Oct 9;48(18):10226-10240
pubmed: 32960220
Oncogene. 2002 May 13;21(21):3368-76
pubmed: 12032775
J Mol Biol. 1961 Jun;3:318-56
pubmed: 13718526
Mol Cell. 2019 Jan 17;73(2):250-263.e5
pubmed: 30527662
Annu Rev Genet. 2018 Nov 23;52:159-183
pubmed: 30183405
J Cell Biol. 2006 Jan 16;172(2):177-87
pubmed: 16418531
Science. 2013 Jun 7;340(6137):1234167
pubmed: 23744951
J Mol Evol. 2004 Jun;58(6):642-52
pubmed: 15461421
PLoS Comput Biol. 2017 Sep 13;13(9):e1005708
pubmed: 28902867
Mol Cell Biol. 2006 Jul;26(13):5096-105
pubmed: 16782894
Cell. 2018 Apr 5;173(2):430-442.e17
pubmed: 29606353
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5675-9
pubmed: 8650150
Cell. 1983 Jan;32(1):45-53
pubmed: 6825173
Curr Opin Genet Dev. 2019 Apr;55:106-113
pubmed: 31491591
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10226-31
pubmed: 11517325
FEMS Microbiol Rev. 2019 Nov 1;43(6):591-607
pubmed: 31301226
Plant Cell. 2021 Apr 17;33(2):290-305
pubmed: 33793769
Semin Cell Dev Biol. 2014 Oct;34:76-84
pubmed: 24930771
Cold Spring Harb Perspect Med. 2012 Dec 01;2(12):a011627
pubmed: 23209182
Biochim Biophys Acta Gene Regul Mech. 2017 Apr;1860(4):393-404
pubmed: 28161275
Genes Dev. 2014 Oct 1;28(19):2151-62
pubmed: 25274727
Cell. 2003 May 2;113(3):405-17
pubmed: 12732147
Nat Genet. 2019 Dec;51(12):1691-1701
pubmed: 31740836
Curr Top Dev Biol. 2008;82:117-39
pubmed: 18282519
Mol Cell Biol. 1991 Sep;11(9):4679-89
pubmed: 1875946
J Immunol. 2004 Oct 1;173(7):4260-4
pubmed: 15383553
Hum Mol Genet. 2001 Feb 15;10(4):371-82
pubmed: 11157800
Mol Biol Evol. 2017 Jun 1;34(6):1492-1504
pubmed: 28333290
Curr Opin Genet Dev. 1996 Aug;6(4):488-95
pubmed: 8791532
Curr Top Dev Biol. 2016;118:45-76
pubmed: 27137654
Chromosome Res. 2003;11(5):447-59
pubmed: 12971721
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1590-5
pubmed: 18216242
Cell. 2007 Jul 27;130(2):373-84
pubmed: 17662950
Biochim Biophys Acta Gene Regul Mech. 2017 Apr;1860(4):416-426
pubmed: 28161276
BMC Biol. 2019 Jul 12;17(1):55
pubmed: 31299961
Genes Cells. 2006 Feb;11(2):123-31
pubmed: 16436049
Curr Opin Cell Biol. 1999 Dec;11(6):699-704
pubmed: 10600714
Blood Cells Mol Dis. 2018 May;70:2-12
pubmed: 28811072
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14494-9
pubmed: 11121052
EMBO J. 2007 Apr 18;26(8):2041-51
pubmed: 17380126
EMBO J. 1999 Jul 15;18(14):4035-48
pubmed: 10406808
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4449-52
pubmed: 10781042
WormBook. 2015 Apr 28;:1-20
pubmed: 25936768
Blood. 2021 Mar 11;137(10):1327-1339
pubmed: 33512425
Int J Biol Sci. 2006;2(3):133-41
pubmed: 16763673
Dev Biol. 2007 Jun 15;306(2):847-59
pubmed: 17448461
Biochemistry (Mosc). 2020 Jun;85(6):643-650
pubmed: 32586227
FASEB J. 2020 Nov;34(11):14736-14749
pubmed: 32924169
Mol Cell Biol. 2011 Aug;31(16):3298-311
pubmed: 21670149
Genes Dev. 1990 Oct;4(10):1637-49
pubmed: 2249769
J Mol Evol. 1974 Feb 28;3(1):1-48
pubmed: 4208305
Acta Physiol (Oxf). 2014 Jul;211(3):501-14
pubmed: 24811692
Nature. 1999 Mar 25;398(6725):344-8
pubmed: 10192336
Front Genet. 2020 Aug 11;11:850
pubmed: 32849830
Nucleic Acids Res. 2009 Dec;37(22):7394-406
pubmed: 19820109
PLoS One. 2011;6(9):e25292
pubmed: 21949889
Epigenetics Chromatin. 2012 Sep 07;5(1):16
pubmed: 22958419
Genes Dev. 2018 Dec 1;32(23-24):1537-1549
pubmed: 30463901
Genome Biol. 2017 Aug 7;18(1):149
pubmed: 28784160
Annu Rev Genet. 1972;6:133-56
pubmed: 4352830
Wiley Interdiscip Rev RNA. 2011 May-Jun;2(3):417-34
pubmed: 21957027
Mol Phylogenet Evol. 2013 Feb;66(2):469-78
pubmed: 22846683
Crit Rev Eukaryot Gene Expr. 2001;11(1-3):227-42
pubmed: 11693962
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21081-6
pubmed: 23204437
J Biol Chem. 2013 Mar 8;288(10):6957-67
pubmed: 23288852
Genome Biol. 2020 Mar 23;21(1):75
pubmed: 32293525
FEBS Lett. 2015 Oct 7;589(20 Pt A):2885-92
pubmed: 26012375
Genome Biol Evol. 2018 Jan 1;10(1):344-358
pubmed: 29340581
J Biol. 2008 Nov 20;7(9):35
pubmed: 19040770
Bioessays. 2001 Sep;23(9):820-30
pubmed: 11536294
Science. 1997 Aug 1;277(5326):696-9
pubmed: 9235894
Nat Cell Biol. 2017 Aug;19(8):952-961
pubmed: 28737770
Nat Rev Microbiol. 2013 Jan;11(1):21-32
pubmed: 23178386
Curr Opin Genet Dev. 2008 Aug;18(4):387-93
pubmed: 18721879
BMC Biol. 2008 Jul 25;6:34
pubmed: 18657265
DNA Cell Biol. 2005 Sep;24(9):529-42
pubmed: 16153154
Physiology (Bethesda). 2016 May;31(3):223-32
pubmed: 27053736
Genomics. 2008 Mar;91(3):243-8
pubmed: 18082363
Cell. 2011 Nov 11;147(4):907-21
pubmed: 22078886
Development. 2007 Jul;134(14):2549-60
pubmed: 17553908