Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells.
Autophagy
/ drug effects
Beclin-1
/ metabolism
Biomarkers
/ metabolism
CARD Signaling Adaptor Proteins
/ genetics
Caspase 1
/ metabolism
Cell Line
Cell Survival
/ drug effects
Cytokines
/ metabolism
Humans
Inflammasomes
/ metabolism
Interleukin-18
/ genetics
Microglia
/ cytology
Microtubule-Associated Proteins
/ metabolism
NLR Family, Pyrin Domain-Containing 3 Protein
/ genetics
Oligopeptides
/ pharmacology
Protein Aggregates
RNA, Messenger
/ genetics
Sequestosome-1 Protein
/ metabolism
Time Factors
Up-Regulation
/ drug effects
tau Proteins
/ pharmacology
Alzheimer’s disease
HMC3
NLRP3
PHF6
autophagy
microglia
tau
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
30 06 2021
30 06 2021
Historique:
received:
17
05
2021
revised:
23
06
2021
accepted:
29
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
29
10
2021
Statut:
epublish
Résumé
Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of Alzheimer's disease (AD). Tau pathology correlates not only with progressive dementia but also with microglia-mediated inflammation in AD. Amyloid-beta (Aβ), another pathogenic peptide involved in AD, has been shown to activate NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3), triggering the secretion of proinflammatory interleukin-1β (IL1β) and interleukin-18 (
Identifiants
pubmed: 34209408
pii: cells10071652
doi: 10.3390/cells10071652
pmc: PMC8304967
pii:
doi:
Substances chimiques
Beclin-1
0
Biomarkers
0
CARD Signaling Adaptor Proteins
0
Cytokines
0
Inflammasomes
0
Interleukin-18
0
MAP1LC3A protein, human
0
Microtubule-Associated Proteins
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Oligopeptides
0
PYCARD protein, human
0
Protein Aggregates
0
RNA, Messenger
0
SQSTM1 protein, human
0
Sequestosome-1 Protein
0
tau Proteins
0
tau hexapeptide PHF6
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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