Adult
Age Factors
Aged
Amyotrophic Lateral Sclerosis
/ genetics
C9orf72 Protein
/ genetics
COVID-19
/ genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Logistic Models
Male
Microsatellite Repeats
Middle Aged
Odds Ratio
Risk Factors
SARS-CoV-2
/ isolation & purification
Severity of Illness Index
C9orf72
COVID-19
SARS-CoV-2
autophagy
genetic risk
innate immunity
intermediate alleles
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 06 2021
29 06 2021
Historique:
received:
12
05
2021
revised:
24
06
2021
accepted:
24
06
2021
entrez:
2
7
2021
pubmed:
3
7
2021
medline:
9
7
2021
Statut:
epublish
Résumé
A cytokine storm, autoimmune features and dysfunctions of myeloid cells significantly contribute to severe coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Genetic background of the host seems to be partly responsible for severe phenotype and genes related to innate immune response seem critical host determinants. The
Identifiants
pubmed: 34209673
pii: ijms22136991
doi: 10.3390/ijms22136991
pmc: PMC8268051
pii:
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ViiV Healthcare
ID : unconditional grant (E.Q-R)
Organisme : Università degli Studi di Brescia
ID : ex 60% (I.Z.)
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : project "Dipartimenti di Eccellenza 2018-2020" to the Department of Medical Biotechnologies University of Siena, Italy (Italian D.L. n.18 March 17, 2020)
Organisme : private donors
ID : for COVID-19 research
Organisme : Azienda Ospedaliero-Universitaria Senese
ID : "Bando Ricerca COVID-19 Toscana"
Organisme : charity fund 2020 from Intesa San Paolo
ID : N. B/2020/0119 "Identificazione delle basi genetiche determinanti la variabilità clinica della risposta a COVID-19 nella popolazione italiana
Investigateurs
Francesca Mari
(F)
Sergio Daga
(S)
Elisa Benetti
(E)
Simone Furini
(S)
Floriana Valentino
(F)
Gabriella Doddato
(G)
Annarita Giliberti
(A)
Rossella Tita
(R)
Mirella Bruttini
(M)
Susanna Croci
(S)
Anna Maria Pinto
(AM)
Maria Antonietta Mencarelli
(MA)
Caterina Lo Rizzo
(C)
Francesca Montagnani
(F)
Laura Di Sarno
(L)
Maria Palmieri
(M)
Miriam Lucia Carriero
(ML)
Massimiliano Fabbiani
(M)
Ilaria Rancan
(I)
Barbara Rossetti
(B)
Elena Bargagli
(E)
Laura Bergantini
(L)
Miriana D'Alessandro
(M)
Paolo Cameli
(P)
David Bennet
(D)
Federico Anedda
(F)
Simona Marcantonio
(S)
Sabino Scolletta
(S)
Federico Franchi
(F)
Maria Antonietta Mazzei
(MA)
Susanna Guerrini
(S)
Edoardo Conticini
(E)
Luca Cantarini
(L)
Bruno Frediani
(B)
Danilo Tacconi
(D)
Chiara Spertilli
(C)
Marco Feri
(M)
Alice Donati
(A)
Raffaele Scala
(R)
Luca Guidelli
(L)
Genni Spargi
(G)
Marta Corridi
Cesira Nenicioni
(C)
Leonardo Croci
(L)
Gian Piero Caldarelli
(GP)
Maurizio Spagnesi
(M)
Davide Romani
(D)
Paolo Piacentini
(P)
Maria Bandini
(M)
Elena Desanctis
(E)
Silvia Cappelli
(S)
Anna Canaccini
(A)
Agnese Verzuri
(A)
Valentina Anemoli
(V)
Agostino Ognibene
(A)
Alessandro Pancrazi
(A)
Maria Lorubbio
(M)
Massimo Vaghu
(M)
Antonella D'Arminio Monforte
(A)
Federica Gaia Miraglia
(FG)
Mario U Monedlli
(MU)
Raffaele Bruno
(R)
Marco Vecchia
(M)
Stefania Mantovani
(S)
Serena Ludovisi
(S)
Massimo Girardis
(M)
Sophie Venturelli
(S)
Stefano Busani
(S)
Andrea Cossarizza
(A)
Andrea Antinori
(A)
Alessandra Vergori
(A)
Arianna Emiliozzi
(A)
Stefano Rusconi
(S)
Matteo Siano
(M)
Arianna Gabrieli
(A)
Agostino Riva
(A)
Daniela Francisci
(D)
Elisabetta Schiaroli
(E)
Francesco Paciosi
(F)
Andrea Tommasi
(A)
Pier Giorgio Scotton
(PG)
Francesca Andretta
Sandro Panese
(S)
Renzo Scaggiante
(R)
Francesca Gatti
(F)
Saverio Giuseppe Parisi
(SG)
Melania degli Antoni
(M)
Matteo Della Monica
(M)
Carmelo Piscopo
(C)
Mario Capasso
(M)
Roberta Russo
(R)
Immacolata Andolfo
(I)
Achille Iolascon
(A)
Giuseppe Fiorentino
(G)
Massimo Carella
(M)
Marco Castori
(M)
Giuseppe Merla
(G)
Gabriella Maria Squeo
(GM)
Filippo Aucella
(F)
Pamela Raggi
(P)
Carmen Marciano
(C)
Rita Perna
(R)
Matteo Bassetti
(M)
Antonio Di Biagio
(A)
Maurizio Sanguinetti
(M)
Luca Masucci
(L)
Serafina Valente
(S)
Marco Mandalà
(M)
Alessia Giorli
(A)
Lorenzo Salerni
(L)
Patrizia Zucchi
(P)
Pierpaolo Parravicini
(P)
Elisabetta Menatti
(E)
Stefano Baratti
(S)
Tullio Trotta
(T)
Ferdinando Giannattasio
(F)
Gabriella Coiro
(G)
Fabio Lena
(F)
Domenico A Coviello
(DA)
Cristina Mussini
(C)
Giancarlo Bosio
(G)
Enrico Martinelli
(E)
Sandro Mancarella
(S)
Luisa Tavecchia
(L)
Mary Ann Belli
(MA)
Lia Crotti
(L)
Gianfranco Parati
(G)
Nicola Picchiotti
(N)
Marco Gori
(M)
Chiara Gabbi
(C)
Maurizio Sanarico
(M)
Stefano Ceri
(S)
Pietro Pinoli
(P)
Francesco Raimondi
(F)
Filippo Biscarini
(F)
Alessandra Stella
(A)
Marco Rizzi
(M)
Franco Maggiolo
(F)
Diego Ripamonti
Claudia Suardi
(C)
Tiziana Bachetti
(T)
Maria Teresa La Rovere
(MT)
Simona Sarzi-Braga
(S)
Maurizio Bussotti
(M)
Katia Capitani
(K)
Kristina Zguro
(K)
Simona Dei
(S)
Sabrina Ravaglia
(S)
Rosangela Artuso
(R)
Antonio Perrella
(A)
Francesco Bianchi
Paola Bergomi
(P)
Emanuele Catena
(E)
Riccardo Colombo
(R)
Valentina Perticaroli
(V)
Massimo Gennarelli
(M)
Chiara Magri
(C)
Giorgio Basiotto
(G)
Daniela Zizioli
(D)
Silvia Giliani
(S)
Eugenio Monti
(E)
Emanuele Focà
(E)
Cannio Carriero
(C)
Nicola Latronico
(N)
Alessandro Padovani
(A)
Duilio Brugnoni
(D)
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