Functional multigenic variations associated with hodgkin lymphoma.
hodgkin lymphoma
microarray
multigenic variations
Journal
International journal of laboratory hematology
ISSN: 1751-553X
Titre abrégé: Int J Lab Hematol
Pays: England
ID NLM: 101300213
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
03
06
2021
received:
30
03
2021
accepted:
09
06
2021
pubmed:
4
7
2021
medline:
15
12
2021
entrez:
3
7
2021
Statut:
ppublish
Résumé
The current study aimed to describe genotypes associated with Hodgkin lymphoma (HL) in a cohort of Saudi and non-Saudi patients and discuss their possible susceptibility to HL. We studied clinical, histopathological, and laboratory findings of HL patients admitted over 12 years duration, at King Fahd University Hospital, KSA. The genomic DNAs of HL patients (n = 61) and normal control subjects (n = 36) were extracted, and genotyping was performed using the Illumina human exome bead chip. Set of HL patients and set of normal controls were included in this study. A total of 35 DNA variants were found to be highly significant with the P-value <9.90 × 10 Our study concludes that the HL is genetically heterogeneous with multigene causation.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1472-1482Subventions
Organisme : The Deanship of Scientific Research
Organisme : Imam Abdulrahman Bin Faisal University
ID : 2017-135-IRMC
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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