Polyamine metabolism is a central determinant of helper T cell lineage fidelity.
Animals
Cell Differentiation
/ drug effects
Cell Lineage
/ drug effects
Cell Polarity
/ drug effects
Cell Proliferation
/ drug effects
Chromatin
/ metabolism
Citric Acid Cycle
/ drug effects
Colitis
/ immunology
Cytokines
/ metabolism
Disease Models, Animal
Enzyme Inhibitors
/ pharmacology
Epigenome
Histones
/ metabolism
Inflammation
/ immunology
Lymphocyte Subsets
/ drug effects
Lysine
/ analogs & derivatives
Mice
Mice, Inbred C57BL
Ornithine Decarboxylase
/ metabolism
Polyamines
/ metabolism
T-Lymphocytes, Helper-Inducer
/ cytology
Th17 Cells
/ drug effects
Transcription Factors
/ metabolism
T cells
eIF5A
hypusine
immunity
immunometabolism
metabolism
polyamines
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
05 08 2021
05 08 2021
Historique:
received:
06
01
2020
revised:
16
02
2021
accepted:
02
06
2021
pubmed:
4
7
2021
medline:
6
1
2022
entrez:
3
7
2021
Statut:
ppublish
Résumé
Polyamine synthesis represents one of the most profound metabolic changes during T cell activation, but the biological implications of this are scarcely known. Here, we show that polyamine metabolism is a fundamental process governing the ability of CD4
Identifiants
pubmed: 34216540
pii: S0092-8674(21)00708-X
doi: 10.1016/j.cell.2021.06.007
pmc: PMC8358979
pii:
doi:
Substances chimiques
Chromatin
0
Cytokines
0
Enzyme Inhibitors
0
Histones
0
Polyamines
0
Transcription Factors
0
hypusine
3874VXF092
Ornithine Decarboxylase
EC 4.1.1.17
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4186-4202.e20Subventions
Organisme : NIAID NIH HHS
ID : R01 AI123322
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests E.L.P. is a SAB member of ImmunoMet, a founder of Rheos Medicines, and an advisory board member for Cell.
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