Integrative biology defines novel biomarkers of resistance to strongylid infection in horses.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
12 07 2021
12 07 2021
Historique:
received:
26
04
2021
accepted:
16
06
2021
entrez:
13
7
2021
pubmed:
14
7
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential. To date, this has been missing in livestock species. Here, we selected Welsh ponies with divergent intrinsic susceptibility (measured by their egg excretion levels) to cyathostomin infection and found that their divergence was sustained across a 10-year time window. Using this unique set of individuals, we monitored variations in their blood cell populations, plasma metabolites and faecal microbiota over a grazing season to isolate core differences between their respective responses under worm-free or natural infection conditions. Our analyses identified the concomitant rise in plasma phenylalanine level and faecal Prevotella abundance and the reduction in circulating monocyte counts as biomarkers of the need for drug treatment (egg excretion above 200 eggs/g). This biological signal was replicated in other independent populations. We also unravelled an immunometabolic network encompassing plasma beta-hydroxybutyrate level, short-chain fatty acid producing bacteria and circulating neutrophils that forms the discriminant baseline between susceptible and resistant individuals. Altogether our observations open new perspectives on the susceptibility of equids to strongylid infection and leave scope for both new biomarkers of infection and nutritional intervention.
Identifiants
pubmed: 34253752
doi: 10.1038/s41598-021-93468-2
pii: 10.1038/s41598-021-93468-2
pmc: PMC8275762
doi:
Substances chimiques
Anthelmintics
0
Biomarkers
0
Phenylalanine
47E5O17Y3R
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14278Informations de copyright
© 2021. The Author(s).
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