Two-Photon, Ratiometric, Quantitative Fluorescent Probe Reveals Fluctuation of Peroxynitrite Regulated by Arginase 1.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
27 07 2021
27 07 2021
Historique:
pubmed:
17
7
2021
medline:
10
8
2021
entrez:
16
7
2021
Statut:
ppublish
Résumé
Peroxynitrite, a transient reactive oxygen species (ROS), is believed to play a deleterious role in physiological processes. Herein, we report a two-photon ratiometric fluorescent probe that selectively reacts with peroxynitrite yielding a >200-fold change upon reaction. The probe effectively visualized fluctuations in peroxynitrite generation by arginase 1 in vivo and in vitro. This provides evidence that arginase 1 is a critical regulator of peroxynitrite.
Identifiants
pubmed: 34269045
doi: 10.1021/acs.analchem.1c00911
doi:
Substances chimiques
Fluorescent Dyes
0
Reactive Oxygen Species
0
Peroxynitrous Acid
14691-52-2
Arginase
EC 3.5.3.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM