Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats.
Animals
Behavior, Animal
Brain Ischemia
/ complications
Cognition
Cognition Disorders
/ etiology
Combined Modality Therapy
Gene Expression
Infarction, Middle Cerebral Artery
/ psychology
Male
Neural Pathways
Phosphorylation
RNA-Seq
Rats
Rats, Sprague-Dawley
Signal Transduction
/ genetics
Transcranial Magnetic Stimulation
/ methods
Cognitive training
Poststroke cognitive impairment
RNA sequencing
rTMS
rTMS-COG
tMCAO
Journal
Brain research bulletin
ISSN: 1873-2747
Titre abrégé: Brain Res Bull
Pays: United States
ID NLM: 7605818
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
20
02
2021
revised:
26
06
2021
accepted:
14
07
2021
pubmed:
20
7
2021
medline:
23
3
2022
entrez:
19
7
2021
Statut:
ppublish
Résumé
Poststroke cognitive impairment (PSCI) occurs frequently after stroke, but lacks effective treatments. Previous studies have revealed that high-frequency repetitive transcranial magnetic stimulation (rTMS) has a beneficial effect on PSCI and is often used with other cognitive training methods to improve its effect. This study aimed to evaluate the effect of different combinations of rTMS and cognitive training (rTMS-COG) on PSCI and identify the optimal combination protocol. A cerebral infarction rat model was established by transient middle cerebral artery occlusion (tMCAO). The Morris water maze test was conducted to assess the cognitive function of rats. RNA sequencing and bioinformatics analysis were employed to study the underlying mechanisms. rTMS, COG and rTMS-COG all had beneficial effects on PSCI, while cognitive training immediately after rTMS (rTMS-COG
Identifiants
pubmed: 34280480
pii: S0361-9230(21)00212-4
doi: 10.1016/j.brainresbull.2021.07.012
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-25Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.