Characterization and visualization of murine coagulation factor VIII-producing cells in vivo.

Animals CD146 Antigen / metabolism Endothelial Cells / metabolism Factor VIII / biosynthesis Green Fluorescent Proteins / metabolism Immunohistochemistry Lectins, C-Type / metabolism Liver / cytology Membrane Glycoproteins / metabolism Mice Platelet Endothelial Cell Adhesion Molecule-1 / metabolism Vesicular Transport Proteins / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
21 07 2021
Historique:
received: 20 04 2021
accepted: 09 07 2021
entrez: 22 7 2021
pubmed: 23 7 2021
medline: 25 11 2021
Statut: epublish

Résumé

Coagulation factors are produced from hepatocytes, whereas production of coagulation factor VIII (FVIII) from primary tissues and cell species is still controversial. Here, we tried to characterize primary FVIII-producing organ and cell species using genetically engineered mice, in which enhanced green fluorescent protein (EGFP) was expressed instead of the F8 gene. EGFP-positive FVIII-producing cells existed only in thin sinusoidal layer of the liver and characterized as CD31

Identifiants

DOI: 10.1038/s41598-021-94307-0 PMID: 34290295 PMC: PMC8295325
pubmed: 34290295
doi: 10.1038/s41598-021-94307-0
pii: 10.1038/s41598-021-94307-0
pmc: PMC8295325
doi:

Substances chimiques

CD146 Antigen 0
CLEC-2 protein, mouse 0
Gp38 protein, mouse 0
LYVE1 protein, mouse 0
Lectins, C-Type 0
Mcam protein, mouse 0
Membrane Glycoproteins 0
Pecam1 protein, mouse 0
Platelet Endothelial Cell Adhesion Molecule-1 0
Vesicular Transport Proteins 0
Green Fluorescent Proteins 147336-22-9
Factor VIII 9001-27-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

14824

Informations de copyright

© 2021. The Author(s).

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Auteurs

Morisada Hayakawa (M)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. morisada@jichi.ac.jp.
Center for Gene Therapy Research, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. morisada@jichi.ac.jp.

Asuka Sakata (A)

Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Hiroko Hayakawa (H)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Hikari Matsumoto (H)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Takafumi Hiramoto (T)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Yuji Kashiwakura (Y)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Nemekhbayar Baatartsogt (N)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Noriyoshi Fukushima (N)

Department of Pathology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Yoichi Sakata (Y)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

Katsue Suzuki-Inoue (K)

Department of Clinical and Laboratory Medicine, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

Tsukasa Ohmori (T)

Department of Biochemistry, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. tohmori@jichi.ac.jp.
Center for Gene Therapy Research, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan. tohmori@jichi.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization and visualization of murine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Antigènes CD146 › Characterization and visualization of murine...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Characterization and visualization of murine...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur VIII › Characterization and visualization of murine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines luminescentes › Protéines à fluorescence verte › Characterization and visualization of murine...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › Characterization and visualization of murine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines de type C › Characterization and visualization of murine...
questionsmedicales.fr › Système digestif › Foie › Characterization and visualization of murine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Characterization and visualization of murine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Characterization and visualization of murine...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Antigènes CD31 › Characterization and visualization of murine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Characterization and visualization of murine...