Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines.

Amides / chemistry Amines / chemistry Oxadiazoles / chemistry
Amide Antioxidant Oxadiazole Synthesis

Journal

Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 27 05 2021
accepted: 05 07 2021
pubmed: 24 7 2021
medline: 23 6 2022
entrez: 23 7 2021
Statut: ppublish

Résumé

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage.

Identifiants

DOI: 10.1007/s11030-021-10275-7 PMID: 34296385
pubmed: 34296385
doi: 10.1007/s11030-021-10275-7
pii: 10.1007/s11030-021-10275-7
doi:

Substances chimiques

Amides 0
Amines 0
Oxadiazoles 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1761-1767

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Références

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Auteurs

Merla Arjuna Rajendra (MA)

Department of Chemistry, SSIT, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, 572107, India.

Muhammad Naseem (M)

College of Natural and Health Sciences, Zayed University, PO Box 144534, Khalifa City, Abu Dhabi, UAE.

Muthipeedika Nibin Joy (MN)

Innovation Center for Chemical and Pharmaceutical Technologies, Institute of Chemical Technology, Ural Federal University, 19 Mira Street, Yekaterinburg, Russia, 620002.

K Sunil (K)

Department of Chemistry, SSIT, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, 572107, India. sunilk999@gmail.com.

Ayyiliath Meleveetil Sajith (AM)

School of Chemical Sciences, Kannur University, Payyanur Campus, Edat, P.O. 670327, Kannur, Kerala, India. sajithmeleveetil@gmail.com.

Fares Howari (F)

College of Natural and Health Sciences, Zayed University, PO Box 144534, Khalifa City, Abu Dhabi, UAE.

Yousef Nazzal (Y)

College of Natural and Health Sciences, Zayed University, PO Box 144534, Khalifa City, Abu Dhabi, UAE.

Cijo Xavier (C)

College of Natural and Health Sciences, Zayed University, PO Box 144534, Khalifa City, Abu Dhabi, UAE.

Mohammed B Alshammari (MB)

Chemistry Department, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, 11942, P.O. Box 83, Al-Kharij, Saudi Arabia.

Karickal Raman Haridas (KR)

School of Chemical Sciences, Kannur University, Payyanur Campus, Edat, P.O. 670327, Kannur, Kerala, India.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amides › Application of NMI-TfCl-mediated amide bond...
questionsmedicales.fr › Composés chimiques organiques › Amines › Application of NMI-TfCl-mediated amide bond...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxadiazoles › Application of NMI-TfCl-mediated amide bond...